Results 81 to 90 of about 3,320,308 (251)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Collision and Merger Products of Stars Do Not Look Alike: A Magnetohydrodynamics Comparison
The Astrophysical JournalA significant fraction of stars experience close interactions, including collisions resulting from gravitational encounters and mergers within close binary systems.
Pavan Vynatheya +4 more
doaj +1 more source
Relativistic stellar jets: dynamics and non-thermal radiation
EPJ Web of Conferences, 2013 Relativistic stellar jets, produced in binary systems called microquasars, propagate through media with different spatial scales releasing their energy in the form of work and radiation from radio to gamma rays.
Bosch-Ramon Valentí
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Editorial: Galactic Dynamics in the Solar Neighborhood
Frontiers in Astronomy and Space Sciences, 2022 Jacques R. D. Lépine
doaj +1 more source
Probing Stellar Kinematics with the Time-Asymmetric Hanbury Brown and Twiss Effect
The Open Journal of AstrophysicsIntensity interferometry (II) offers a powerful means to observe stellar objects with a high resolution. In this work, we demonstrate that II can also probe internal stellar kinematics by revealing a time-asymmetric Hanbury Brown and Twiss (HBT) effect ...
Lucijana Stanic +13 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Iron Snails: Nonequilibrium Dynamics and Spiral Abundance Patterns
The Astrophysical JournalGalaxies are not in a dynamical steady state: they continually undergo perturbations, e.g., from infalling dwarf galaxies and dark matter substructure. After a dynamical perturbation, stars phase mix toward a new steady state; in so doing, they generally
Neige Frankel +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source