Results 301 to 310 of about 3,026,820 (400)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Relativistic stage of stellar evolution

Вісник Астрономічної школи, 2001
V. I. Zhdanov
doaj   +1 more source

Science development study for the Atacama Large Aperture Submillimeter Telescope (AtLAST): Solar and stellar observations. [PDF]

Open Res Eur
Wedemeyer S, Barta M, Brajša R, Chai Y, Costa J, Gary D, Gimenez de Castro G, Gunar S, Fleishman G, Hales A, Hudson H, Kirkaune M, Mohan A, Motorina G, Pellizzoni A, Saberi M, Selhorst CL, Simoes PJA, Shimojo M, Skokić I, Sudar D, Menezes F, White SM, Booth M, Klaassen P, Cicone C, Mroczkowski T, Cordiner MA, Di Mascolo L, Johnstone D, van Kampen E, Lee M, Liu D, Maccarone T, Orlowski-Scherer J, Saintonge A, Smith M, Thelen AE.   +37 more
europepmc   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

The erosion of large primary atmospheres typically leaves behind substantial secondary atmospheres on temperate rocky planets. [PDF]

Nat Commun
Krissansen-Totton J, Wogan N, Thompson M, Fortney JJ.   +3 more
europepmc   +1 more source

Massive star populations in I Zw 18: A probe of stellar evolution in the early universe

, 1998
D. Schaerer, D. F. de Mello, Claus Leitherer, J. L. Heldmann   +3 more
openalex   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Rotation and Stellar Evolution [PDF]

Monthly Notices of the Royal Astronomical Society, 1953
openaire   +2 more sources

One month convection timescale on the surface of a giant evolved star. [PDF]

Nature
Vlemmings W, Khouri T, Bojnordi Arbab B, De Beck E, Maercker M.   +4 more
europepmc   +1 more source