Results 321 to 330 of about 2,843,859 (384)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Arabinogalactan proteins answer a great puzzle. [PDF]

Cell Surf
Lamport DTA.
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Long-term Doppler imaging of the star XX Trianguli indicates chaotic non-periodic dynamo. [PDF]

Nat Commun
Strassmeier KG, Kővári Z, Weber M, Granzer T.   +3 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

High-temperature ²⁰⁵Tl decay clarifies ²⁰⁵Pb dating in early Solar System. [PDF]

Nature
Leckenby G, Sidhu RS, Chen RJ, Mancino R, Szányi B, Bai M, Battino U, Blaum K, Brandau C, Cristallo S, Dickel T, Dillmann I, Dmytriiev D, Faestermann T, Forstner O, Franczak B, Geissel H, Gernhäuser R, Glorius J, Griffin C, Gumberidze A, Haettner E, Hillenbrand PM, Karakas A, Kaur T, Korten W, Kozhuharov C, Kuzminchuk N, Langanke K, Litvinov S, Litvinov YA, Lugaro M, Martínez-Pinedo G, Menz E, Meyer B, Morgenroth T, Neff T, Nociforo C, Petridis N, Pignatari M, Popp U, Purushothaman S, Reifarth R, Sanjari S, Scheidenberger C, Spillmann U, Steck M, Stöhlker T, Tanaka YK, Trassinelli M, Trotsenko S, Varga L, Vescovi D, Wang M, Weick H, Yagüe Lopéz A, Yamaguchi T, Zhang Y, Zhao J.   +58 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

An Abrupt Change in the Disk Fraction of Free-Floating Planets at the Deuterium-Burning Ignition Limit

Rodrigues T, Bouy H, Raymond S, Martín E, Bertin E, Romero JO, Barrado D, Huélamo N, Tamura M, Roig NM, Galli P, Cuillandre J.   +11 more
europepmc   +1 more source

Characterizing the luminosity components of luminous infrared galaxies in multi-wavelength from the X-ray to the far-infrared. [PDF]

Sci Rep
Ali AAM, Gadallah KAK, Shalabiea OM, Beheary MM.   +3 more
europepmc   +1 more source