Results 321 to 330 of about 3,026,820 (400)
Presolar Grains as Probes of Supernova Nucleosynthesis. [PDF]
Liu N+4 more
europepmc +1 more source
HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang+11 more
wiley +1 more source
Witnessing the onset of reionization through Lyman-α emission at redshift 13. [PDF]
Witstok J+36 more
europepmc +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo+2 more
wiley +1 more source
Primordial black holes and their gravitational-wave signatures. [PDF]
Bagui E+20 more
europepmc +1 more source
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He+5 more
wiley +1 more source
A Theory of Stellar Evolution [PDF]
openaire +2 more sources
Formation of free-floating planetary mass objects via circumstellar disk encounters. [PDF]
Fu Z, Deng H, Lin DNC, Mayer L.
europepmc +1 more source