Results 61 to 70 of about 214,380 (335)
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali+3 more
wiley +1 more source
Stellar Winds on the Main-Sequence II: the Evolution of Rotation and Winds
Aims: We study the evolution of stellar rotation and wind properties for low-mass main-sequence stars. Our aim is to use rotational evolution models to constrain the mass loss rates in stellar winds and to predict how their properties evolve with time on
Brott, I.+3 more
core +1 more source
Stellar Evolution at Low Metallicity [PDF]
AbstractMassive stars played a key role in the early evolution of the Universe. They formed with the first halos and started the re-ionisation. It is therefore very important to understand their evolution. In this review, we first recall the effect of metallicity (Z) on the evolution of massive stars.
Hirschi, Raphael+4 more
openaire +4 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
Living with a Red Dwarf: X-Ray, UV, and Ca ii Activity–Age Relationships of M Dwarfs
The vast majority of stars in the nearby stellar neighborhood are M dwarfs. Their low masses and luminosities result in slow rates of nuclear evolution and minimal changes to the stars’ observable properties, even along astronomical timescales.
Scott G. Engle
doaj +1 more source
Stellar Yields and Chemical Evolution [PDF]
Several speakers at this symposium have alluded to the zeroth-order agreement between the Type II supernovae (SNe) stellar yields, as predicted by the models of those most responsible for driving progress in the field - i.e. Arnett (1991,1996); Maeder (1992); Woosley & Weaver (1995); Langer & Henkel (1995); Thielemann et al.
openaire +4 more sources
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi+3 more
wiley +1 more source
The ups and downs of inferred cosmological lithium [PDF]
I summarize the stellar side of the cosmological lithium problem(s). Evidence from independent studies is accumulating and indicates that stars may very well be fully responsible for lowering their surface lithium from the predicted primordial value to ...
Korn Andreas
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Pulsating stars are universally recognized as precise distance indicators and tracers of stellar populations. Their variability, combined with well-defined relationships between pulsation properties and intrinsic evolutionary parameters such as ...
Giulia De Somma+3 more
doaj +1 more source