Results 141 to 150 of about 1,362,486 (349)

Stellar feedback in M83 as observed with MUSE [PDF]

, 2022
Lorenza Della Bruna, Angela Adamo, P. Amram, Erik Rosolowsky, Christopher Usher, Mattia Sirressi, Andreas Schruba, Éric Emsellem, Adam K. Leroy, Arjan Bik, William P. Blair, Anna F. McLeod, Göran Östlin, Florent Renaud, Carmelle Robert, Laurie Rousseau-Nepton, L. J. Smith   +16 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The M81 Group Dwarf Irregular Galaxy DDO 165. II. Connecting Recent Star Formation with ISM Structures and Kinematics

, 2011
We compare the stellar populations and complex neutral gas dynamics of the M81 group dIrr galaxy DDO 165 using data from the HST and the VLA. Paper I identified two kinematically distinct HI components, multiple localized high velocity gas features, and ...
Andrew E. Dolphin, Anil Seth, Bagetakos, Bellazzini, Bertelli, Chandar, Croxall, Daniel R. Weisz, David Cook, de Blok, Evan D. Skillman, Fabian Walter, Fall, Gil de Paz, Hans P. Most, Heckman, Janice Lee, John M. Cannon, Joung, Joung, Kellman, Kennicutt, Kim, Kobulnicky, Kobulnicky, Kobulnicky, Kunth, Lee, Leitherer, Mac Low, McQuinn, Oh, Rhode, Robert C. Kennicutt, Schlegel, Steven R. Warren, Sánchez-Salcedo, Thomasson, van der Hulst, Walter, Walter, Walter, Warren, Weisz, Weisz, Weisz   +45 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Why Do Semianalytic Models Predict Higher Scatter in the Stellar Mass–Halo Mass Relation Than Cosmological Hydrodynamic Simulations?

The Astrophysical Journal
Semianalytic models (SAMs) systematically predict higher-stellar mass scatter at a given halo mass than hydrodynamical simulations and most empirical models. Our goal is to investigate the physical origin of this scatter by exploring modifications to the
Antonio J. Porras-Valverde, John C. Forbes, Rachel S. Somerville, Adam R. H. Stevens, Kelly Holley-Bockelmann, Andreas A. Berlind, Shy Genel   +6 more
doaj   +1 more source

Stellar Ages and Metallicities of Central and Satellite Galaxies: Implications for Galaxy Formation and Evolution

, 2009
Using a large SDSS galaxy group catalogue, we study how the stellar ages and metallicities of central and satellite galaxies depend on stellar mass and halo mass.
Bosch, Frank C. van den, De Lucia, Gabriella, Fontanot, Fabio, Gallazzi, Anna, Mo, H. J., Pasquali, Anna, Yang, Xiaohu   +6 more
core   +1 more source

A stellar feedback origin for neutral hydrogen in high-redshift quasar-mass haloes [PDF]

, 2016
Observations of quasar pairs reveal that quasar host halos at z ~ 2 have large covering fractions of cool dense gas (≳ 60% for Lyman limit systems within a projected virial radius).
C. Faucher-Giguére, R. Feldmann, E. Quataert, D. Keres̆, P. Hopkins, N. M. Northwestern, Uc Berkeley, U. Diego, Caltech, Cita   +9 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source