Results 141 to 150 of about 1,357,920 (351)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Exploring the Evolution of a Dwarf Spheroidal Galaxy with SPH Simulations. II. AGN Feedback

The Astrophysical Journal
We investigate active galactic nucleus (AGN) feedback from an intermediate-mass black hole at the center of a dwarf spheroidal galaxy, by performing isolated galaxy simulations using a modified version of the GADGET-3 code. We consider Leo II (PGC 34176)
Roberto Hazenfratz, Paramita Barai, Gustavo A. Lanfranchi, Anderson Caproni   +3 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Why Do Semianalytic Models Predict Higher Scatter in the Stellar Mass–Halo Mass Relation Than Cosmological Hydrodynamic Simulations?

The Astrophysical Journal
Semianalytic models (SAMs) systematically predict higher-stellar mass scatter at a given halo mass than hydrodynamical simulations and most empirical models. Our goal is to investigate the physical origin of this scatter by exploring modifications to the
Antonio J. Porras-Valverde, John C. Forbes, Rachel S. Somerville, Adam R. H. Stevens, Kelly Holley-Bockelmann, Andreas A. Berlind, Shy Genel   +6 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A stellar feedback origin for neutral hydrogen in high-redshift quasar-mass haloes [PDF]

, 2016
Observations of quasar pairs reveal that quasar host halos at z ~ 2 have large covering fractions of cool dense gas (≳ 60% for Lyman limit systems within a projected virial radius).
C. Faucher-Giguére, R. Feldmann, E. Quataert, D. Keres̆, P. Hopkins, N. M. Northwestern, Uc Berkeley, U. Diego, Caltech, Cita   +9 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

SYGMA: Stellar Yields for Galactic Modeling Applications

, 2018
The stellar yields for galactic modeling applications (SYGMA) code is an open-source module that models the chemical ejecta and feedback of simple stellar populations (SSPs).
Côté, Benoit, Fryer, Chris L., Herwig, Falk, Navarro, Julio F., Ritter, Christian   +4 more
core   +1 more source