Results 51 to 60 of about 55,503 (265)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The nature and origin of disky elliptical galaxies [PDF]

, 2002
The observational trend that disky elliptical galaxies exhibit younger luminosity- weighted ages than boxy ellipticals is investigated. The presence of a possible young stellar disk embedded in these galaxies is explored by comparing kinematics derived ...
McDermid, Richard Morgan
core  

The magnetic fields of intermediate-mass T Tauri stars. I. Magnetic detections and fundamental stellar parameters [PDF]

, 2019
International audienceContext : .The origin of the fossil magnetic fields detected in 5 to 10% of intermediate-mass main sequence stars is still highly debated.
Johns-Krull, C., F. Gallet, Lebreton, Y.,, Johns-Krull, C.,, Bouvier, J.,, Petit, P., Haemmerlé, L., Böhm, T., T. Böhm, Charbonnel, C.,, J. Morin, Haemmerle, L.,, Marsden, S. C., Charbonnel, Corinne, Marsden, C., Morin, J., L. Haemmerlé, Kochukhov, Oleg,, Lebreton, Y., Petit, P.,, C. Charbonnel, Charbonnel, C., Alecian, E.,, Amard, L.,, Hussain, G.,, Alecian, E., Morin, J.,, Folsom, C. P.,, G. Hussain, S. C. Marsden, Folsom, C. P., P. Petit, Hussain, G., Amard, L., E. Alecian, C. Johns-Krull, Marsden, S. C.,, L. Amard, J. Bouvier, C. P. Folsom, Villebrun, F.,, Y. Lebreton, Bouvier, J., O. Kochukhov, Gallet, F.,, Folsom, C., Bohm, T.,, Villebrun, F., Gallet, F., Kochukhov, O., F. Villebrun   +50 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

LEGA-C stellar population scaling relations

Astronomy & Astrophysics
We analysed a sample of 552 galaxies from the LEGA-C spectroscopic survey (0.6 
Gallazzi Anna R., Zibetti Stefano, van der Wel Arjen, Nersesian Angelos, Kaushal Yasha, Bezanson Rachel, Mattolini Daniele, Bell Eric F., Scholz-Diaz Laura, Leja Joel, D’Eugenio Francesco, Wu Po-Feng, Pacifici Camilla, Maseda Michael   +13 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

On the masses and evolutionary status of the black hole binary GX 339-4: a twin system of XTE J1550-564?

, 2008
We apply the K-correction to the black hole low-mass X-ray binary (LMXB) GX 339-4 which implies MX? 6 M? by only assuming that the companion is more massive than ?0.17 M?, the lower limit allowed by applying a ‘stripped-giant’ model.
Munoz-Darias, T., I. G. Martínez-Pais, Martinez-Pais, I.G., Casares, J., T. Muñoz-Darias, J. Casares   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The effects of stellar winds on the magnetospheres and potential habitability of exoplanets

, 2014
V.S. acknowledges the support of an STFC studentship. A.A.V. acknowledges support from a Royal Astronomical Society Fellowship and an Ambizione Fellowship from the Swiss National Science Foundation. S.V.J.
S. C. Marsden, Jeffers, Sandra V., P. Petit, S. V. Jeffers, Jardine, M., M. Jardine, A. A. Vidotto, Vidotto, A. A., Petit, P., V. See, Do Nascimento, J.D., J. D. do Nascimento, do Nascimento, Jose-Dias Jr., do Nascimento Jr., J. D., Jeffers, S.V., See, Wyke Chun Victor, Vidotto, A.A., Marsden, S. C., See, V., Jeffers, S. V., Marsden, S.C.   +20 more
core   +1 more source

The First Systematic Survey of Stellar Halos in High-inclination Galaxies Reveals Unusually Quiescent Merger Histories of Nearby Galaxies

The Astrophysical Journal Supplement Series
Stellar halos are the only major stellar component of disk galaxies that lack systematic observational characterization, yet they encode critical information about galaxy merger histories.
Bojun Tao, Hong-Xin Zhang, Wenting Wang, Enci Wang, Guangwen Chen, Huiyuan Wang, Lijun Chen, Qian-Hui Chen, Song Huang, Xu Kong, Yu Rong   +10 more
doaj   +1 more source