Results 231 to 240 of about 46,211 (288)

The Progenitor Systems of Classical Novae in M31. [PDF]

Astrophys J
Abelson CS, Badenes C, Chomiuk L, Williams BF, Breivik K, Galbany L, Jiménez-Palau C.   +6 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Determination of the mass distribution of the first stars from the 21-cm signal. [PDF]

Nat Astron
Gessey-Jones T, Sartorio NS, Bevins HTJ, Fialkov A, Handley WJ, de Lera Acedo E, Mirouh GM, Izzard RG, Barkana R.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A massive compact quiescent galaxy at z = 2 with a complete Einstein ring in JWST imaging. [PDF]

Nat Astron
van Dokkum P, Brammer G, Wang B, Leja J, Conroy C.   +4 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Precision analysis of NGC 2158 with Gaia DR3. [PDF]

Sci Rep
Ahmed NM, Tadross AL.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A rising tide: intrinsic alignments since the turn of the millennium. [PDF]

Astron Astrophys Rev
Chisari NE.
europepmc   +1 more source

JWST detection of heavy neutron capture elements in a compact object merger

, 2023
Levan A, Gompertz B, Salafia OS, Bulla M, Burns E, Hotokezaka K, Izzo L, Lamb G, Malesani D, Oates S, Ravasio M, Escorial AR, Schneider B, Sarin N, Schulze S, Tanvir N, Ackley K, Anderson G, Brammer G, Christensen L, Dhillon V, Evans P, Fausnaugh M, Fong W, Fruchter A, Fryer C, Fynbo J, Gaspari N, Heintz K, Hjorth J, Kennea J, Kennedy M, Laskar T, Leloudas G, Mandel I, Martín-Carrillo A, Metzger B, Nicholl M, Nugent A, Palmerio J, Pugilese G, Rastinejad J, Rhodes L, Rossi A, Smartt S, Stevance H, Tohuvavohu A, Horst Avd, Vergani S, Watson D, Barclay T, Bhirombhakdi K, Breedt E, Breeveld A, Brown A, Campana S, D'Avanzo P, D'Elia V, De Pasquale M, Dyer M, Galloway D, Garbutt J, Green M, Hartmann D, Jakobsson P, Kerry P, Langeroodi D, Leung J, Littlefair S, Munday J, O'Brien P, Parsons S, Pelisoli I, Sahman D, Salvaterra R, Tagliaferri G, Thöne C, Postigo AdU, Sbarufatti B, Chrimes A, Steeghs D, Kann D.   +81 more
europepmc   +1 more source