Results 31 to 40 of about 974 (262)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks   +5 more
wiley   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille   +9 more
wiley   +1 more source

Structure and evolution of high-mass stellar mergers [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2013
In young dense clusters repeated collisions between massive stars may lead to the formation of a very massive star (above 100 Msun). In the past the study of the long-term evolution of merger remnants has mostly focussed on collisions between low-mass stars (up to about 2 Msun) in the context of blue-straggler formation.
Glebbeek, E.   +3 more
openaire   +3 more sources

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar   +7 more
wiley   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot   +6 more
wiley   +1 more source

MOSEL Survey: JWST Reveals Major Mergers/strong Interactions Drive the Extreme Emission Lines in the Early Universe

open access: yesThe Astrophysical Journal Letters, 2023
Extreme emission line galaxies (EELGs), where nebular emissions contribute 30%–40% of the flux in certain photometric bands, are ubiquitous in the early Universe ( z > 6).
Anshu Gupta   +9 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall   +2 more
wiley   +1 more source

Mergers of accreting stellar-mass black holes [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2016
We present post-Newtonian $N$-body simulations on mergers of accreting stellar-mass black holes (BHs), where such general relativistic effects as the pericenter shift and gravitational wave (GW) emission are taken into consideration. The attention is concentrated on the effects of the dynamical friction and the Hoyle-Lyttleton mass accretion by ambient
Tagawa, Hiromichi   +2 more
openaire   +3 more sources

Stellar Mass Assembly History of Massive Quiescent Galaxies since z ∼ 4: Insights from Spatially Resolved Spectral Energy Distribution Fitting with JWST Data

open access: yesThe Astrophysical Journal
Massive quiescent galaxies at high redshift show significantly more compact morphology than their local counterparts. To examine their internal structure across a wide redshift range and investigate potential redshift dependence, we performed spatially ...
Novan Saputra Haryana   +14 more
doaj   +1 more source

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