Results 101 to 110 of about 373 (258)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

The Upper Atmosphere of Uranus from Stellar Occultations. II. Revised Temperatures in the Upper Stratosphere and Lower Thermosphere

The Planetary Science Journal
Measurements made by Voyager 2 during its flyby of Uranus in 1986 found warm stratospheric and hot thermospheric temperatures that cannot be explained by solar energy alone.
William R. Saunders, Michael J. Person, Paul Withers, Richard G. French, Chanita Tubthong   +4 more
doaj   +1 more source

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

Advanced Science, EarlyView.
Freestanding hierarchical‐porous BCZT thin films integrate a compliant porous surface with a dense piezoceramic backbone to balance mechanical reliability, voltage sensitivity, and acoustic coupling. The films enable stable wearable pulse‐wave monitoring and enhanced tissue‐coupled ultrasonic energy harvesting, offering a promising route toward soft ...
Zifan Li, Shengwei Gao, Wang Hong, Yuxin Chen, Yiyang Gu, Xu Wang, Chen Tang, Ying Hong, Xuemu Li, Xiaodong Yan, Yi Zheng, Yiming Liu, Junchen Liao, Biao Wang, Shiyuan Liu   +14 more
wiley   +1 more source

Rigorous Use of Light-curve Inversion and Stellar Occultation Techniques for Deriving a Scaled Three-dimensional Shape for the Jupiter Trojan (911) Agamemnon

The Astrophysical Journal
This work presents a methodology for determining the size, three-dimensional shape, and rotational parameters of small solar system objects, with rigorous uncertainty determination, using stellar occultations, rotational and phase-angle light curves ...
Eros de O. Gradovski, Felipe Braga-Ribas, Altair R. Gomes-Junior, Bruno Sicardy, Jose Luis Ortiz, Giuliano Margoti, Chrystian L. Pereira, Pablo Santos-Sanz, Konrad Guhl, Josselin Desmars, Yucel Kilic, Nicolás Morales, Roberto Vieira-Martins, Rafael Sfair, Bruno Morgado, Julio I. B. de Camargo, Marcelo Assafin, Fabio A. Spina, Flavia Rommel, Gustavo Benedetti-Rossi, Jonatã Arcas-Silva, Luan M. Catani, Luana Liberato, Patricia Buzzatto, Thamiris de Santana, Vadim Nikitin, Jan Mánek, Mehmed N. Bağiran, Suleyman Fisek, Tim Haymes, Alberto J. Castro-Tirado, Alfonso Noschese, Alper K. Ates, Andrea Manna, Anna Marciniak, Antonio S. Amador, Carles Schnabel, Christine C. Gao, Christoph M. Schafer, Eda Sonbas, Faustino Organero, Fuat K. Yelkenci, Gregor Krannich, Ignacio de la Cueva, Jesús Castano, James Eisfeldt, Jean Bourgeois, Johnny Barton, Jose F. Águila, Jose L. Maestre, Karl-Ludwig Bath, Kevin Green, Leonor Ana, Malcolm Jennings, Maria Gritsevich, Martin Gutekunst, Mert Acar, Oguzhan Cakir, Olivier Schreurs, Peter Tickner, Roland Boninsegna, Selami Kalkan, Sinan Alis, Stefano Sposetti, Steve Messner, Waldemar Ogloza   +65 more
doaj   +1 more source

Jupiter Science Enabled by ESA's Jupiter Icy Moons Explorer. [PDF]

Space Sci Rev, 2023
Fletcher LN, Cavalié T, Grassi D, Hueso R, Lara LM, Kaspi Y, Galanti E, Greathouse TK, Molyneux PM, Galand M, Vallat C, Witasse O, Lorente R, Hartogh P, Poulet F, Langevin Y, Palumbo P, Gladstone GR, Retherford KD, Dougherty MK, Wahlund JE, Barabash S, Iess L, Bruzzone L, Hussmann H, Gurvits LI, Santolik O, Kolmasova I, Fischer G, Müller-Wodarg I, Piccioni G, Fouchet T, Gérard JC, Sánchez-Lavega A, Irwin PGJ, Grodent D, Altieri F, Mura A, Drossart P, Kammer J, Giles R, Cazaux S, Jones G, Smirnova M, Lellouch E, Medvedev AS, Moreno R, Rezac L, Coustenis A, Costa M.   +49 more
europepmc   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

No thick carbon dioxide atmosphere on the rocky exoplanet TRAPPIST-1 c. [PDF]

Nature, 2023
Zieba S, Kreidberg L, Ducrot E, Gillon M, Morley C, Schaefer L, Tamburo P, Koll DDB, Lyu X, Acuña L, Agol E, Iyer AR, Hu R, Lincowski AP, Meadows VS, Selsis F, Bolmont E, Mandell AM, Suissa G.   +18 more
europepmc   +1 more source