Results 111 to 120 of about 373 (258)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Juno's Close Encounter With Ganymede-An Overview. [PDF]

Geophys Res Lett, 2022
Hansen CJ, Bolton S, Sulaiman AH, Duling S, Bagenal F, Brennan M, Connerney J, Clark G, Lunine J, Levin S, Kurth W, Mura A, Paranicas C, Tosi F, Withers P.   +14 more
europepmc   +1 more source

Photoactivation‐Enabled Tunable Room‐Temperature Phosphorescence and Thermally Activated Delayed Fluorescence in Crystalline Materials

Advanced Science, EarlyView.
This work is the first to demonstrate the regulation of photoactivated room‐temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) in crystalline materials without any pretreatment. Furthermore, we reveal the underlying mechanisms by uncovering the role of host‐guest energy level alignment, exciton lifetime, crystallinity,
Lisha Zhang, Yongping Wu, Ihor Sahalianov, Lei Zhou, Glib Baryshnikov, Xiang Ma   +5 more
wiley   +1 more source

Prediction and Observation of a Stellar Occultation by Haumea’s Satellite Namaka

Research Notes of the AAS
Abstract Stellar occultations are an ideal way to characterize the physical and orbital properties of trans-Neptunian binary systems. In this research note, we detail the prediction and observation of a stellar occultation observed with NASA’s Infrared Telescope Facility on 2025 March 16th (UT), with drop-outs from both the dwarf planet ...
Flavia L. Rommel, Benjamin C. N. Proudfoot, Bryan J. Holler, Jose L. Ortiz, Estela Fernández-Valenzuela   +4 more
openaire   +2 more sources

An exomoon survey of 70 cool giant exoplanets and the new candidate Kepler-1708 b-i. [PDF]

Nat Astron, 2022
Kipping D, Bryson S, Burke C, Christiansen J, Hardegree-Ullman K, Quarles B, Hansen B, Szulágyi J, Teachey A.   +8 more
europepmc   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Constraints on Quaoar’s Rings and Atmosphere from JWST/NIRCam Observations of a Stellar Occultation

The Planetary Science Journal
Observations of stellar occultations have revealed that small bodies are capable of hosting ring systems. The trans-Neptunian object Quaoar is the host of an enigmatic ring system, with two rings located well outside the Roche limit. To better understand
Benjamin Proudfoot, Bryan J. Holler, Ko Arimatsu, Flavia L. Rommel, Cameron Collyer, Estela Fernández-Valenzuela   +5 more
doaj   +1 more source

Observation based climatology Martian atmospheric waves perturbation Datasets. [PDF]

Sci Data, 2023
Zhang J, Ji Q, Sheng Z, He M, He Y, Zuo X, He Z, Qin Z, Wu G.   +8 more
europepmc   +1 more source

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

Advanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato, Jesús A. Andrés‐San Román, Juan Garrido‐García, Carmen Gordillo‐Vázquez, Ana M. Palacios, Elisabeth Lidueña‐Fernández, Katie McDole, Pedro Gómez‐Gálvez, Valentina Annese, Luis M. Escudero   +9 more
wiley   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source