Results 131 to 140 of about 373 (258)

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

JWST stellar occultation reveals unexpected changes in Chariklo's ring system. [PDF]

Sci Adv
Santos-Sanz P, Gomes-Júnior AR, Morgado BE, Kilic Y, Kalup C, Kiss C, Pereira CL, Holler BJ, Morales N, Ortiz JL, Sicardy B, Rizos JL, Stansberry J, French RG, Hammel HB, Lin ZY, Souami D, Desmars J, Milam SN, Braga-Ribas F, Assafin M, Benedetti-Rossi G, Camargo JIB, Duffard R, Rommel FL, Fernández-Valenzuela E, Pinilla-Alonso N, Vara-Lubiano M.   +27 more
europepmc   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Exospheric Temperature Measured by NASA-GOLD Under Low Solar Activity: Comparison With Other Data Sets. [PDF]

J Geophys Res Space Phys, 2022
Park J, Evans JS, Eastes RW, Lumpe JD, van den Ijssel J, Englert CR, Stevens MH.   +6 more
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Inter-comparison of Mars Upper Atmosphere Neutral Density and Temperature Datasets from MAVEN. [PDF]

Space Sci Rev
Jones N, Evans JS, Gupta S, Jain S, Pilinski M, Stone SW, Thiemann EMB, Schneider N, Curry S.   +8 more
europepmc   +1 more source

The Ionospheric Connection Explorer - Prime Mission Review. [PDF]

Space Sci Rev, 2023
Immel TJ, England SL, Harding BJ, Wu YJ, Maute A, Cullens C, Englert CR, Mende SB, Heelis RA, Frey HU, Korpela EJ, Stephan AW, Frey S, Stevens MH, Makela JJ, Kamalabadi F, Triplett CC, Forbes JM, McGinness E, Gasque LC, Harlander JM, Gérard JC, Hubert B, Huba JD, Meier RR, Roberts B.   +25 more
europepmc   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Waves in Cassini UVIS stellar occultations [PDF]

Icarus, 2011
Kévin Baillié, Joshua E. Colwell, Jack J. Lissauer, Larry W. Esposito, Miodrag Sremčević   +4 more
openaire   +1 more source