Results 181 to 190 of about 346 (266)

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

Combined analysis of the 12.8 and 15 microns JWST/MIRI eclipse observations of TRAPPIST-1 b

, 2023
Ducrot E, Lagage P, Min M, Gillon M, Bell T, Tremblin P, Greene T, Dyrek A, Waters R, Güdel M, Henning T, Vandenbussche B, Absil O, Barrado D, Boccaletti A, Coulais A, Decin L, Edwards B, Gastaud R, Bouwman J, Glasse A, Kendrew S, Olofsson G, Patapis P, Pye J, Rouan D, Whiteford N, Argyriou I, Cossou C, Glauser A, Krause O, Lahuis F, Royer P, Scheithauer S, Colina L, Dishoeck Ev, Östlin G, Ray T, Wright G.   +38 more
europepmc   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Neptune and Uranus: ice or rock giants? [PDF]

Philos Trans A Math Phys Eng Sci, 2020
Teanby NA, Irwin PGJ, Moses JI, Helled R.   +3 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Characterization of the Surfaces and Near-Surface Atmospheres of Ganymede, Europa and Callisto by JUICE. [PDF]

Space Sci Rev
Tosi F, Roatsch T, Galli A, Hauber E, Lucchetti A, Molyneux P, Stephan K, Achilleos N, Bovolo F, Carter J, Cavalié T, Cimò G, D'Aversa E, Gwinner K, Hartogh P, Huybrighs H, Langevin Y, Lellouch E, Migliorini A, Palumbo P, Piccioni G, Plaut JJ, Postberg F, Poulet F, Retherford K, Rezac L, Roth L, Solomonidou A, Tobie G, Tortora P, Tubiana C, Wagner R, Wirström E, Wurz P, Zambon F, Zannoni M, Barabash S, Bruzzone L, Dougherty M, Gladstone R, Gurvits LI, Hussmann H, Iess L, Wahlund JE, Witasse O, Vallat C, Lorente R.   +46 more
europepmc   +1 more source

A Review of Possible Planetary Atmospheres in the TRAPPIST-1 System. [PDF]

Space Sci Rev, 2020
Turbet M, Bolmont E, Bourrier V, Demory BO, Leconte J, Owen J, Wolf ET.   +6 more
europepmc   +1 more source

Intelligent Stain‐Free Histology on Structural Colorimetric Nanocavities

Advanced Science, EarlyView.
Chen and Gan et al. introduce a label‐free imaging platform using inexpensive Nanocavity‐on‐Silicon (NOS) slides. These slides transform subtle tissue variations into vivid structural colors, enabling high‐contrast histological imaging under a regular optical microscope. This stain‐free approach reveals morphological details comparable to traditional H&
Qizhe Chen, Yifei Ren, Lijie Hu, Yanyan Li, Wenyue Liang, Jin Wang, Han Gao, Xinhai Wang, Jiajun Li, Qiutao He, Yingfeng Zhu, Haifeng Hu, Qiwen Zhan, Imed Gallouzi, Jasmeen Merzaban, Di Wang, Zunguo Du, Xiaodong Gu, Qiaoqiang Gan   +18 more
wiley   +1 more source

H₃⁺ as an ionospheric sounder of Jupiter and giant planets: an observational perspective. [PDF]

Philos Trans A Math Phys Eng Sci, 2019
Drossart P.
europepmc   +1 more source