Results 111 to 120 of about 165,855 (235)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Concealing Circumbinary Planets with Tidal Shrinkage

open access: yesThe Astrophysical Journal
Of the 14 transiting planets that have been detected orbiting eclipsing binaries (“circumbinary planets”), none have been detected with stellar binary orbital periods shorter than 7 days, despite such binaries existing in abundance.
Saahit Mogan, J.J. Zanazzi
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

The Impact of Local Stellar Radiation on Dwarf Galaxy Formation around Milky Way Analogs across Cosmic Reionization

open access: yesThe Astrophysical Journal
We explore the effect of local stellar radiation on the formation and evolution of dwarf galaxies around Milky Way (MW) analogs. Using five simulations from the Auriga project, both with and without local stellar radiation, we find that local stellar ...
Bocheng Zhu, Liang Gao
doaj   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale

open access: yesThe Astrophysical Journal Letters
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj   +1 more source

Home - About - Disclaimer - Privacy