Results 121 to 130 of about 171,691 (281)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Stellar Mass Segregation in Dark Matter Halos

The Astrophysical Journal
We study the effect of stellar mass segregation driven by collisional relaxation within the potential well of a smooth dark matter halo. This effect is of particular relevance for old stellar systems with short crossing times, where small collisional ...
Raphaël Errani, Jorge Peñarrubia, Matthew G. Walker   +2 more
doaj   +1 more source

Stellar evolution and stellar populations

, 2019
I will overview how the theory of stellar evolution and stellar populations evolved to explain the rich features observed in large surveys of the Magellanic Clouds -- going from subtle features in colour-magnitude diagrams to striking sequences in period-magnitude diagrams.
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A Study of Primordial Very Massive Star Evolution. II. Stellar Rotation and Gamma-Ray Burst Progenitors

The Astrophysical Journal
We calculate new evolutionary models of rotating primordial very massive stars, with initial mass from 100 M _⊙ to 200 M _⊙ , for two values of the initial metallicity Z = 0 and Z = 0.0002.
Guglielmo Volpato, Paola Marigo, Guglielmo Costa, Alessandro Bressan, Michele Trabucchi, Léo Girardi, Francesco Addari   +6 more
doaj   +1 more source

Stellar population in star formation regions of galaxies

Open Astronomy, 2018
We developed techniques for searching young unresolved star groupings (clusters, associations, and their complexes) and of estimating their physical parameters.
Gusev Alexander S., Shimanovskaya Elena V., Shatsky Nikolai I., Sakhibov Firouz, Piskunov Anatoly E., Kharchenko Nina V.   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Impact of Orbital Anisotropy Assumptions in Lensing-dynamics Modeling

The Astrophysical Journal
We investigate potential systematic biases introduced by assumptions regarding stellar orbital anisotropy in joint lensing-dynamics modeling. Using massive early-type galaxies from the TNG100 simulation at redshifts z = 0.2, 0.5, and 0.7, we generate a ...
Yan Liang, Dandan Xu, Anowar J. Shajib, Yiping Shu, Ran Li   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source