Results 141 to 150 of about 174,695 (330)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Impact of Local Stellar Radiation on Dwarf Galaxy Formation around Milky Way Analogs across Cosmic Reionization

The Astrophysical Journal
We explore the effect of local stellar radiation on the formation and evolution of dwarf galaxies around Milky Way (MW) analogs. Using five simulations from the Auriga project, both with and without local stellar radiation, we find that local stellar ...
Bocheng Zhu, Liang Gao
doaj   +1 more source

Astro2020 Science White Paper: Science Platforms for Resolved Stellar Populations in the Next Decade [PDF]

, 2019
Knut Olsen, M. L. Graham, Dara Norman, S. Juneau, A. Bolton   +4 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Stellar population study in early-type galaxies: an approach from the K band [PDF]

, 2009
E. Mármol-Queraltó, N. Cardiel, P. Sánchez–Blázquez, S. C. Trager, R. F. Peletier, H. Kuntschner, David R. Silva, A. J. Cenarro, A. Vazdekis, J. Gorgas   +9 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The stellar population of bulges [PDF]

, 2008
To appear in the proceedings of the conference The Metal-Rich Universe, held June 12-16 on La Palma, Spain ...
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Photometric Evidence of an Intermediate-age Stellar Population in the Inner Bulge of M31 [PDF]

, 2015
H. Dong, Jun Yi Koay, Q. Daniel Wang, Tod R. Lauer, Knut Olsen, Abhijit Saha, Julianne J. Dalcanton, Benjamin F. Williams   +7 more
openalex   +1 more source

On the complex stellar populations of ancient stellar systems [PDF]

, 2018
Het bestuderen van oeroude sterren in hedendaagse, nabije sterrenstelsels om hun geschiedenis te reconstrueren valt onder de noemer van stellaire archeologie. In de afgelopen jaren hebben nauwkeurige observaties onthuld dat veel oude sterrensystemen in de buurt van de Melkweg complexer zijn dan daarvoor was aangenomen.
openaire   +2 more sources