Results 251 to 260 of about 108,892 (343)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Strong gravitational lenses from the Vera C. Rubin Observatory. [PDF]

Philos Trans A Math Phys Eng Sci
Shajib AJ, Smith GP, Birrer S, Verma A, Arendse N, Collett T, Daylan T, Serjeant S, LSST Strong Lensing Science Collaboration.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Formation of a low-mass galaxy from star clusters in a 600-million-year-old Universe. [PDF]

Nature
Mowla L, Iyer K, Asada Y, Desprez G, Tan VYY, Martis N, Sarrouh G, Strait V, Abraham R, Bradač M, Brammer G, Muzzin A, Pacifici C, Ravindranath S, Sawicki M, Willott C, Estrada-Carpenter V, Jahan N, Noirot G, Matharu J, Rihtaršič G, Zabl J.   +21 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Coronal dimmings and what they tell us about solar and stellar coronal mass ejections. [PDF]

Living Rev Sol Phys
Veronig AM, Dissauer K, Kliem B, Downs C, Hudson HS, Jin M, Osten R, Podladchikova T, Prasad A, Qiu J, Thompson B, Tian H, Vourlidas A.   +12 more
europepmc   +1 more source

Determining the impact of post-main-sequence stellar evolution on the transiting giant planet population [PDF]

Edward M. Bryant, Vincent Van Eylen
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Perspectives on the physics of late-type stars from beyond low earth orbit, the moon and mars. [PDF]

NPJ Microgravity
Mathur S, Santos ÂRG.
europepmc   +1 more source

INSPIRE: INvestigating Stellar Population In RElics – VII. The local environment of ultra-compact massive galaxies [PDF]

Diana Scognamiglio, Chiara Spiniello, M. Radovich, C. Tortora, N. R. Napolitano, Rui Li, M. Maturi, Michalina Maksymowicz-Maciata, Michele Cappellari, M. Arnaboldi, Davide Bevacqua, L. Coccato, G. D’Ago, Hai-Cheng Feng, Anna Ferré-Mateu, Johanna Hartke, Ignacio Martín-Navarro, C. Pulsoni   +17 more
openalex   +1 more source