Results 231 to 240 of about 15,741 (301)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Total Neoadjuvant Therapy for Rectal Cancer: Why Japan Says "Not Yet". [PDF]

Ann Gastroenterol Surg
Uehara K, Matsuda A, Yamada T, Monkhonsupphawan A, Yoshida H.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

Nature
Poulain M, Smith R, Duc PA, Marleau FR, Habas R, Durrell PR, Fensch J, Lim S, Müller O, Paudel S, Sánchez-Janssen R.   +10 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Photometric detection at 7.7 μm of a galaxy beyond redshift 14 with JWST/MIRI. [PDF]

Nat Astron
Helton JM, Rieke GH, Alberts S, Wu Z, Eisenstein DJ, Hainline KN, Carniani S, Ji Z, Baker WM, Bhatawdekar R, Bunker AJ, Cargile PA, Charlot S, Chevallard J, D'Eugenio F, Egami E, Johnson BD, Jones GC, Lyu J, Maiolino R, Pérez-González PG, Rieke MJ, Robertson B, Saxena A, Scholtz J, Shivaei I, Sun F, Tacchella S, Whitler L, Williams CC, Willmer CNA, Willott C, Witstok J, Zhu Y.   +33 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Extreme properties of a compact and massive accreting black hole host in the first 500 Myr. [PDF]

Nat Commun
Tripodi R, Martis N, Markov V, Bradač M, Di Mascia F, Cammelli V, D'Eugenio F, Willott C, Curti M, Bhatt M, Gallerani S, Rihtaršič G, Singh J, Gaspar G, Harshan A, Judež J, Merida RM, Desprez G, Sawicki M, Goovaerts I, Muzzin A, Noirot G, Sarrouh GTE, Abraham R, Asada Y, Brammer G, Estrada-Carpenter V, Felicioni G, Fujimoto S, Iyer K, Mowla L, Strait V.   +31 more
europepmc   +1 more source