Results 221 to 230 of about 1,811,299 (294)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Discs no more: the morphology of low-mass simulated galaxies in FIREbox. [PDF]

Mon Not R Astron Soc
Benavides JA, Sales LV, Wetzel A, Moreno J, Feldmann R, Mercado FJ, Bullock JS, Hopkins PF, Faucher-Giguère CA, Stern J, Wheeler C, Kereš D.   +11 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Sotatercept in Children with Pulmonary Hypertension-A Narrative Review. [PDF]

Children (Basel)
Schulz J, Stark VC, Harbaum L, Kozlik-Feldmann R, Mir TS, Stute F, Olfe J.   +6 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Sotatercept in pulmonary arterial hypertension: revolution, risk and the road ahead. [PDF]

Eur Respir J
Hoeper MM.
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A large, long-lived, slowly-expanding superbubble across the Perseus arm. [PDF]

Nat Commun
Chen B, Li G, Yuan H, Xiang M, Zhou J, Chen P, Krause M, Coombs A.   +7 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

A gas-enshrouded and gas-reddened black hole at cosmic dawn. [PDF]

Nature
Naidu RP, Matthee J, Katz H, de Graaff A, Oesch PA, Smith A, Greene JE, Brammer G, Weibel A, Hviding R, Chisholm J, Labbé I, Simcoe RA, Witten C, Sun WQ, Atek H, Baggen JFW, Belli S, Bezanson R, Boogaard LA, Bose S, Bouwens RJ, Covelo-Paz A, Dayal P, Fudamoto Y, Furtak LJ, Giovinazzo E, Goulding A, Gronke M, Heintz KE, Hirschmann M, Illingworth G, Inoue AK, Johnson BD, Leja J, Leonova E, McConachie I, Maseda MV, Natarajan P, Nelson E, Setton DJ, Shivaei I, Sobral D, Stefanon M, Tacchella S, Toft S, Torralba A, van Dokkum P, van der Wel A, Volonteri M, Walter F, Wang B, Watson D, Whitaker K.   +53 more
europepmc   +1 more source