Results 71 to 80 of about 6,518 (266)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Impulsive Mixing of Stellar Populations in Dwarf Spheroidal Galaxies

open access: yesThe Astrophysical Journal
We study the response of mono-energetic stellar populations with initially isotropic kinematics to impulsive and adiabatic changes to an underlying dark matter potential.
Raphaël Errani   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Testing the Breakdown of the Asteroseismic Scaling Relations in Luminous Red Giants

open access: yesThe Astrophysical Journal
Nearly all cool, evolved stars are solar-like oscillators, and fundamental stellar properties can be inferred from these oscillations with asteroseismology.
Amanda L. Ash   +3 more
doaj   +1 more source

The Stellar Population of M17

open access: yesThe Astrophysical Journal, 2008
The stellar content of M17 has been investigated by multicolor photometry and spectroscopy. Various independent estimates yield a distance of 2.1 ± 0.2 kpc. The ratio of total-to-selective extinction is R = 3.9. Within a projected area of 3.6 × 3.7 pc, there are several thousand stars.
Hoffmeister, V. H.   +6 more
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

PANCAKE: A Python-based Numerical Color–Magnitude Diagram Analysis Package

open access: yesThe Astrophysical Journal Supplement Series
Stellar populations serve as a fossil record of galaxy formation and evolution, providing crucial information about the history of star formation and galaxy evolution.
Yun Zheng   +13 more
doaj   +1 more source

Home - About - Disclaimer - Privacy