Results 51 to 60 of about 2,111 (247)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Self-consistent Nonlinear Classical Cepheid Pulsations during Stellar Evolution with MESA

The Astrophysical Journal
We extend the time-dependent convection (TDC) treatment in MESA by introducing eddy-viscous dissipation. This software change brings MESA-TDC into closer alignment with the radial stellar pulsation (RSP) framework of the MESA-RSP module.
Ebraheem Farag, Earl P. Bellinger, Philip Mocz, Selim Kalici, Radoslaw Smolec, Shashi Kanbur, Kyra Bettwy, Christopher Lindsay   +7 more
doaj   +1 more source

Opacity Effects on Pulsations of Main-Sequence A-Type Stars

Atoms, 2018
Opacity enhancements for stellar interior conditions have been explored to explain observed pulsation frequencies and to extend the pulsation instability region for B-type main-sequence variable stars.
Joyce A. Guzik, Christopher J. Fontes, Chris Fryer   +2 more
doaj   +1 more source

Left Ringing: Betelgeuse Illuminates the Connection between Convective Outbursts, Mode Switching, and Mass Ejection in Red Supergiants

The Astrophysical Journal, 2023
Betelgeuse, the nearest red supergiant, dimmed to an unprecedented level in early 2020. The star emerged from this “Great Dimming” episode with its typical, roughly 400 days pulsation cycle halved, and a new dominant period of around 200 days.
Morgan MacLeod, Andrea Antoni, Caroline D. Huang, Andrea Dupree, Abraham Loeb   +4 more
doaj   +1 more source

Variability and stellar pulsation incidence in Am and Fm stars using TESS and Gaia data [PDF]

BackgroundRemote and digital consulting in primary care has rapidly expanded since March 2020. It is important to understand patient experiences, particularly for those living with complex long-term conditions, to identify how care can best be delivered,
Dürfeldt-Pedros, O., S. Murphy, Murphy, S., O. Dürfeldt-Pedros, B. Smalley, N. Posilek, Posilek, N., Smalley, B., Niemczura, E., V. Antoci, E. Niemczura, Antoci, V.   +11 more
core   +1 more source

Calibration of the convective parameters in stellar pulsation hydrocodes

, 2023
Despite the appearance of two- and three-dimensional models thanks to the rapid growth of computing performance, numerical hydrocodes used to model radial stellar pulsations still apply a one-dimensional stellar envelope model without any realistic ...
Szabó, Róbert, Nuspl, János, Kovács, Gábor B.   +2 more
core   +1 more source

Challanges for stellar pulsation and evolution theory [PDF]

Communications in Asteroseismology, 2009
During the last few decades, great effort has been made towards understanding hydrodynamical processes which determine the structure and evolution of stars. Up to now, the most stringent constraints have been provided by helioseismology and stellar cluster studies. However, the contribution of asteroseismology becomes more and more important, giving us
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A “Wonderful” Reference Dataset of Mira Variables

Galaxies
The conditions in Mira variable atmospheres make them wonderful laboratories to study a variety of stellar physics such as molecule–grain formation, dust production, shock chemistry, stellar winds, mass loss, opacity-driven pulsation, and shocks. We were
Dana K. Baylis-Aguirre, Michelle J. Creech-Eakman, Gerard T. van Belle   +2 more
doaj   +1 more source