Results 71 to 80 of about 1,827 (268)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
EPJ Web of Conferences, 2017 Over the recent years, the Petersen diagram for classical pulsators, Cepheids and RR Lyr stars, populated with a few hundreds of new multiperiodic variables. We review our analyses of the OGLE data, which resulted in a significant extension of the known,
Smolec Radoslaw +6 more
doaj +1 more source
Opacity Effects on Pulsations of Main-Sequence A-Type Stars
Atoms, 2018 Opacity enhancements for stellar interior conditions have been explored to explain observed pulsation frequencies and to extend the pulsation instability region for B-type main-sequence variable stars.
Joyce A. Guzik +2 more
doaj +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Asteroseismic inferences from the study of non-linearities in δ Sct stars
Frontiers in Astronomy and Space Sciences, 2022 Many pulsating star light curves must be interpreted strictly within the framework of a non-linear theory. The detection of non-linear interactions between pulsation modes has increased due to the ultra-precise photometric data provided by space missions.
Mariel Lares-Martiz
doaj +1 more source
Reminiscence of a Stellar Pulsation Theorist [PDF]
, 1990 The author started working in stellar pulsation theory in 1965. Since this time, we have studied the effects of improved radiative transfer and dynamic zoning on models of Cepheids, RR Lyrae, and W Virginis stars. In this paper we discuss the relevant equations and some results in comparisons to observations of W Virginis and long-period Cepheids. Some
openaire +2 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
The Role of Opacities in Stellar Pulsation
, 2018 6 pages, 3 Figures, Proceeding for the "Workshop on Astrophysical Opacities"
Kanbur, S. M. +4 more
openaire +3 more sources
Stellar Mass Loss and Pulsation [PDF]
International Astronomical Union Colloquium, 1989 AbstractMass loss at rates sufficient to alter the evolution of stars is known to occur during the pre-main sequence evolution of most stars, on the main sequence for massive stars, and during advanced evolutionary phases when the luminosity is high and the effective temperature is low.
openaire +2 more sources