Results 51 to 60 of about 3,384 (302)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Listening to stars: audio-inspired multimodal learning for star classification

Frontiers in Astronomy and Space Sciences
Stellar spectral classification plays a crucial role in understanding the intrinsic properties of stars, such as their temperature, composition, and luminosity.
Shengwen Zhang, Shengwen Zhang, Yanxia Zhang, Chao Liu   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

SpecCLIP: Aligning and Translating Spectroscopic Measurements for Stars

The Astrophysical Journal
In recent years, large language models (LLMs) have transformed natural language understanding through vast data sets and large-scale parameterization. Inspired by this success, we present SpecCLIP, a foundation model framework that extends LLM-inspired ...
Xiaosheng Zhao, Yang Huang, Guirong Xue, Xiao Kong, Jifeng Liu, Xiaoyu Tang, Timothy C. Beers, Yuan-Sen Ting, A-Li Luo   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Simulations of stellar variability: the effect of magnetic features on rotational and transit lightcurves [PDF]

, 2023
Stellar variability (on timescales of days or longer) results predominantly from surface manifestations of magnetic activity such as starspots and faculae, and is one of the most important limiting factors in the detection and characterisation of ...
Johnson, Luke Jonathan
core   +1 more source

Spectral Modes Estimation Using Whittle-Type Criterion, Applications To Stellar Speckle Interferometry.

, 2002
Publication in the conference proceedings of EUSIPCO, Toulouse, France ...
Y. Cavallin, André Ferrari, H. Lanteri
openaire   +3 more sources

A New Approach to the Study of Stellar Populations in Early‐Type Galaxies:K‐Band Spectral Indices and an Application to the Fornax Cluster [PDF]

The Astrophysical Journal, 2008
New measurements of K-band spectral features are presented for eleven early-type galaxies in the nearby Fornax galaxy cluster. Based on these measurements, the following conclusions have been reached: (1) in galaxies with no signatures of a young stellar component, the K-band Na I index is highly correlated with both the optical metallicity indicator ...
Silva, D. R., Kuntschner, H., Lyubenova, M.   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source