Results 171 to 180 of about 1,100,727 (344)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The Astrophysical JournalWe present ∼0.″2 (∼80 au) resolution observations of the CO(2–1) and SiO(5–4) lines made with the Atacama large millimeter/submillimeter array toward an extremely young intermediate-mass protostellar source ( t _dyn < 1000 yr), MMS 1 located in the Orion
Satoko Takahashi +13 more
doaj +1 more source
Star formation in early-type galaxies: the role of stellar winds and kinematics [PDF]
, 2015 Silvia Pellegrini +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Astrophysical JournalWe numerically construct a series of axisymmetric rotating magnetic wind solutions, aiming at exploring the observation properties of massive white dwarf (WD) merger remnants with a strong magnetic field, a fast spin, and an intense mass loss, as ...
Yici Zhong +4 more
doaj +1 more source
Interaction of the Exoplanet Hat–P–11b with Stellar Wind
, 2023 E. S. Belenkaya
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Astrophysical JournalWe perform 2D global magnetohydrodynamic (MHD) simulations including the full nonideal MHD effects (ohmic diffusion, Hall effect, and ambipolar diffusion) and approximate radiation transport to understand the dynamics and thermal structure of the inner ...
Shoji Mori, Xue-Ning Bai, Kengo Tomida
doaj +1 more source
Interaction of Infall and Winds in Young Stellar Objects
, 1999 Guy Delamarter, Adam Frank, Lee Hartmann
openalex +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source