Results 191 to 200 of about 1,165,162 (267)

Stem-cell regulation in periodontium formation and regeneration. [PDF]

J Bone Miner Metab
Nagata M, Nagaoka C, Iwata T.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Harnessing the stem cell potential in the human hippocampus to limit cognitive aging. [PDF]

PLoS Biol
Mhatre S, Moore DL.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Telomere length and clonal hematopoiesis interact to influence outcomes in hematopoietic stem cell transplantation. [PDF]

Blood Adv
Tobin J, Stelmach P, Richter S, Xu D, Sauer S, Raab MS, Gu M, Dunn WG, Fabre MA, Müller-Tidow C, Vassiliou GS.   +10 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The challenges of choosing your pluripotent stem cell line. [PDF]

Stem Cell Reports
Barker RA, Kirkeby A.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A new dawn for Parkinson's disease: commentary on the emergence of stem cell-based therapies. [PDF]

Transl Neurodegener
Elvira R, Chooi WH, Wang H, Tan EK, Zhou ZD.   +4 more
europepmc   +1 more source

RETRACTION: Novel C‐Terminal Heat Shock Protein 90 Inhibitors Target Breast Cancer Stem Cells and Block Migration, Self‐Renewal, and Epithelial–Mesenchymal Transition

Molecular Oncology, EarlyView.
wiley   +1 more source