Results 171 to 180 of about 817,109 (355)

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Erratum: Dynamic niches in the origination and differentiation of haematopoietic stem cells [PDF]

, 2011
Leo D. Wang, Amy J. Wagers
openalex   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

The Broken Cradle: Bone Marrow Stem Cell Niche Remodelling in Diabetes. [PDF]

Stem Cell Rev Rep
Kum JJY, Howlett CJ, Khan ZA.
europepmc   +1 more source

Author response: Embryonic attenuated Wnt/β-catenin signaling defines niche location and long-term stem cell fate in hair follicle

, 2015
Zijian Xu, Wenjie Wang, Kaiju Jiang, Zhou Yu, Huanwei Huang, Fengchao Wang, Bin Zhou, Ting Chen   +7 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Stem Cell Niche Concept: Search for Current Expert Consensus. [PDF]

Int J Mol Sci
Khlusov I, Litvinova L, Efimenko A.
europepmc   +1 more source

Maintenance of niche architecture requires actomyosin and enables proper stem cell signaling and oriented division in the Drosophila testis

Gabriela S. Vida, Elizabeth Botto, Stephen DiNardo   +2 more
openalex   +1 more source

Peritoneal Milky Spots Serve as a Hypoxic Niche and Favor Gastric Cancer Stem/Progenitor Cell Peritoneal Dissemination Through Hypoxia-Inducible Factor 1α [PDF]

, 2014
Zhi‐Feng Miao, Zhenning Wang, Tingting Zhao, Yingying Xu, Jian Gao, Feng Miao, Huimian Xu   +6 more
openalex   +1 more source

Haematopoietic stem cell activity and interactions with the niche

Nature reviews. Molecular cell biology, 2019
Sandra Pinho, P. Frenette
semanticscholar   +1 more source