Results 221 to 230 of about 817,109 (355)

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

The Role of Macrophages in Implementing the Effects of Secretome of Mesenchymal Stromal Cells in the Spermatogonial Stem Cell Niche. [PDF]

Sovrem Tekhnologii Med
Monakova AO, Basalova NA, Balabanyan VY, Kryshen KL, Matichin AA, Sagaradze GD, Popov VS, Efimenko AY.   +7 more
europepmc   +1 more source

Influence of Organ Culture on the Characteristics of the Human Limbal Stem Cell Niche. [PDF]

Int J Mol Sci, 2023
Polisetti N, Martin G, Ulrich E, Glegola M, Schlötzer-Schrehardt U, Schlunck G, Reinhard T.   +6 more
europepmc   +1 more source

Microprinted Stem Cell Niches Reveal Compounding Effect of Colony Size on Stromal Cells‐Mediated Neural Differentiation

, 2017
Ramila Joshi, Pradip Shahi Thakuri, James C. Buchanan, Jun Li, Hossein Tavana   +4 more
openalex   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Genetic map of the carotid body stem cell niche with focus on the O₂-sensing chemoreceptor cell lineage. [PDF]

Sci Rep
Santamaría-Santiago A, Sobrino V, Luna-Ramírez L, López-Barneo J, Pardal R.   +4 more
europepmc   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision. [PDF]

Genes Dis
Liu J, Jiang Z, Zha J, Lin Q, He W.
europepmc   +1 more source

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

, 2014
Hayley L. Belnoue-Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Chiara Bardella, Emma Jaeger, Annabelle Lewis, Luke Freeman-Mills, Francesc Castro-Giner, Pedro Rodenas-Cuadrado, Sreelakshmi Mallappa, Susan K. Clark, Huw Thomas, Rosemary Jeffery, Richard Poulsom, Manuel Rodriguez‐Justo, Marco Novelli, Runjan Chetty, Andrew Silver, Owen J. Sansom, Florian R. Greten, Lai Mun Wang, James E. East, Ian Tomlinson, Simon J. Leedham   +25 more
openalex   +1 more source

WOX5 Suppresses CYCLIN D Activity to Establish Quiescence at the Center of the Root Stem Cell Niche [PDF]

, 2014
Céline Forzani, Ernst Aichinger, Emily Sornay, Viola Willemsen, Thomas Laux, Walter Dewitte, J. A. H. Murray   +6 more
openalex   +1 more source