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Advanced Functional Materials, 2022
Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory bone disease. Stem cell therapies hold great promise for a variety of diseases, but their translation is hampered by ...
Gang Li +9 more
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Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory bone disease. Stem cell therapies hold great promise for a variety of diseases, but their translation is hampered by ...
Gang Li +9 more
semanticscholar +1 more source
The Journal of Pathology, 2008
AbstractVirtually every tissue of the adult organism maintains a population of putatively slowly‐cycling stem cells that maintain homeostasis of the tissue and respond to injury when challenged. These cells are regulated and supported by the surrounding microenvironment, referred to as the stem cell ‘niche’.
M R, Walker +2 more
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AbstractVirtually every tissue of the adult organism maintains a population of putatively slowly‐cycling stem cells that maintain homeostasis of the tissue and respond to injury when challenged. These cells are regulated and supported by the surrounding microenvironment, referred to as the stem cell ‘niche’.
M R, Walker +2 more
openaire +2 more sources
Biology Bulletin, 2007
The nature of the stem cell niche and its interaction with stem cells is one of fundamental problems in the biology of stem cells. Stem cell niches are formed during ontogeny. A niche can remain vacant and exist independently of stem cells; however, stem cell self-renewal cannot be maintained for long periods outside of the niche except for particular ...
V. V. Terskikh +2 more
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The nature of the stem cell niche and its interaction with stem cells is one of fundamental problems in the biology of stem cells. Stem cell niches are formed during ontogeny. A niche can remain vacant and exist independently of stem cells; however, stem cell self-renewal cannot be maintained for long periods outside of the niche except for particular ...
V. V. Terskikh +2 more
openaire +3 more sources
Annual Review of Plant Biology, 2012
Multicellular organisms possess pluripotent stem cells to form new organs, replenish the daily loss of cells, or regenerate organs after injury. Stem cells are maintained in specific environments, the stem cell niches, that provide signals to block differentiation.
Aichinger, Ernst +3 more
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Multicellular organisms possess pluripotent stem cells to form new organs, replenish the daily loss of cells, or regenerate organs after injury. Stem cells are maintained in specific environments, the stem cell niches, that provide signals to block differentiation.
Aichinger, Ernst +3 more
openaire +3 more sources
Science, 2006
A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells.
Moore, Kateri A., Lemischka, Ihor R.
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A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells.
Moore, Kateri A., Lemischka, Ihor R.
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2015
Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies.
Almeida, Raquel Carvalho Ferreira Costa +5 more
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Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies.
Almeida, Raquel Carvalho Ferreira Costa +5 more
openaire +2 more sources
Advanced Functional Materials, 2019
Poor retention rate, low targeting accuracy, and spontaneous transformation of stem cells present major clinical barriers to the success of therapies based on stem cell transplantation.
I. Yasa +4 more
semanticscholar +1 more source
Poor retention rate, low targeting accuracy, and spontaneous transformation of stem cells present major clinical barriers to the success of therapies based on stem cell transplantation.
I. Yasa +4 more
semanticscholar +1 more source
Cell and Tissue Research, 2007
The neural stem cell niche defines a zone in which stem cells are retained after embryonic development for the production of new cells of the nervous system. This continual supply of new neurons and glia then provides the postnatal and adult brain with an added capacity for cellular plasticity, albeit one that is restricted to a few specific zones ...
Joanne C, Conover, Ryan Q, Notti
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The neural stem cell niche defines a zone in which stem cells are retained after embryonic development for the production of new cells of the nervous system. This continual supply of new neurons and glia then provides the postnatal and adult brain with an added capacity for cellular plasticity, albeit one that is restricted to a few specific zones ...
Joanne C, Conover, Ryan Q, Notti
openaire +2 more sources
Adult haematopoietic stem cell niches
Nature Reviews Immunology, 2017Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of ...
Genevieve M, Crane +2 more
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