Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation [PDF]
, 2012 Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a ...
Amoureux +76 more
core +4 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Nutrition and Metabolic Insights, 2022 Background: Cancer survival is associated with body mass index (BMI). However, the impact of patients’ baseline characteristics on allogeneic hematopoietic stem cell transplantation (allo-HSCT) outcomes remains unclear.
Takashi Aoyama +8 more
doaj +1 more source
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
New England Journal of Medicine, 2009 Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-
G. Hütter +12 more
semanticscholar +1 more source
Stem cell sources for regenerative medicine: the immunological point of view [PDF]
, 2018 Stem cell transplantation consists in the introduction of stem cells or derived products in a diseased organism. Because of the differentiation properties of stem cells, the goal is to replace damaged cells or tissues.
Krause, Karl-Heinz +1 more
core
FLT3 mutations in Early T-Cell Precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors [PDF]
, 2013 Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults.
Baldus, Claudia D. +21 more
core +3 more sources
Efficiency of amniotic membrane transplantation in the management of limbal stem cell deficiency [PDF]
, 2020 State University of Medicine and Pharmacy “Nicolae Testemiţanu”, Department of Ophthalmology-Optometry, Chișinău, Republic of Moldova, State University of Medicine and Pharmacy “Nicolae Testemiţanu”, Department of Surgery no.
Cușnir, Valeriu +4 more
core +2 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides Demonstrates Different Alloreactivity Potential In HLA-Matched and Mismatched Donor-Recipient Pairs [PDF]
arXiv, 2015 Stem cell transplants may be considered as dynamical systems to allow sequence differences across the exomes of the transplant donors and recipients to be used to simulate an alloreactive T cell response. Whole exome sequencing was performed on HLA matched stem cell transplant donor-recipient pairs, and the nucleotide sequence differences translated to
arxiv
Hematopoietic stem cell transplantation for patients with AML in first complete remission.
Blood, 2016 Postremission therapy in patients with acute myeloid leukemia (AML) may consist of continuing chemotherapy or transplantation using either autologous or allogeneic stem cells.
J. Cornelissen, D. Blaise
semanticscholar +1 more source