Results 231 to 240 of about 269,242 (268)

Stem cell transplantation for thalassaemia

Reproductive BioMedicine Online, 2005
Although improvements in conventional treatment have enhanced the prognosis of thalassaemia, stem cell transplantation remains the only cure. Over the last 2 decades, progress in preventive strategies, effective control of transplant related complications and development of new preparative regimens, have considerably improved the results of transplants
Javid, Gaziev, Guido, Lucarelli
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Role of Stem Cell Transplantation

Hematology/Oncology Clinics of North America, 2007
Hematopoietic stem cell transplantation (SCT) was introduced in the treatment of multiple myeloma in the 1980s. In the autologous setting, the use of peripheral blood stem cells instead of bone marrow has markedly improved feasibility. In fit patients who have normal renal function and are younger than 65 years of age, randomized studies have shown the
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Stem Cell Transplantation Methods

2010
Just a few short years ago, we still used to think that we were born with a finite number of irreplaceable neurons. However, in recent years, there has been increasingly persuasive evidence that suggests that neural stem cell (NSC) maintenance and differentiation continue to take ace throughout the mammal's lifetime.
Kimberly D, Tran, Allen, Ho, Rahul, Jandial   +2 more
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Stem cell transplantation for hemoglobinopathies

Current Opinion in Pediatrics, 2003
Hereditary anemias caused by beta-thalassemia and sickle cell disease are the most common genetic diseases worldwide. Supportive therapies such as chronic lifelong transfusions, iron chelation for thalassemia, and transfusions or hydroxyurea for sickle cell anemia have significantly ameliorated clinical manifestations of these diseases but cannot ...
Javid, Gaziev, Guido, Lucarelli
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Spermatogonial stem cell transplantation

Molecular and Cellular Endocrinology, 2000
The development of the spermatogonial transplantation technique has given new impetus to research on spermatogonial stem cells. Possibilities opened by this technique include: (a) New ways to study fundamental aspects of spermatogenesis; (b) Generation of transgenic large domestic animals; (c) Protection of (young) male cancer patients from infertility
Izadyar, F., Creemers, L. B., van Dissel-Emiliani, F. M., van Pelt, A. M., de rooij, D. G.   +4 more
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Stem Cell Transplantation for Myelodysplasia

2001
The natural course of MDS varies considerably depending upon patient age and findings at the time of diagnosis. Life expectancy ranges from years in early stages to only a few months in advanced stages. The disease can rapidly progress to acute leukemia, and the prognosis for patients with advanced MDS (RAEB, RAEBT) and therapy-related (secondary) MDS ...
H G, Klingemann, H J, Deeg
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Stem Cell Transplantation in Hemoglobinopathies

Hemoglobin, 2007
beta-Thalassemia (thal) and sickle cell disease are the most common genetic diseases worldwide. Although supportive therapies such as regular transfusion and chelation for beta-thal and hydroxyurea (HU) for sickle cell disease have significantly improved clinical manifestations and the quality of life, they cannot eliminate disease and therapy-related ...
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In utero stem cell transplantation

Best Practice & Research Clinical Obstetrics & Gynaecology, 2004
In utero haematopoietic cell transplantation (IUHCT) is a promising approach for the treatment of a variety of genetic disorders. The rationale is to take advantage of normal events during haematopoietic and immunological ontogeny to facilitate allogeneic haematopoietic engraftment.
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Neural Transplantation and Stem Cells

2009
Recent results have raised important questions on our ability to amplify stem cell populations in sufficient numbers as to be useful for therapy. Several reports have indicated that human stem cell populations harvested from the adult have low or undetectable telomerase levels, age in culture, and may not be propagated indefinitely.
Mahendra S, Rao, Mohan C, Vemuri
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Stem cells: Transplants on trial

Nature, 2011
Stem-cell transplants are an important tool for treating myeloma. But with improved drug alternatives, doctors disagree about the best time to give the treatment.
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