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Stem Cell Transplantation Methods
2010Just a few short years ago, we still used to think that we were born with a finite number of irreplaceable neurons. However, in recent years, there has been increasingly persuasive evidence that suggests that neural stem cell (NSC) maintenance and differentiation continue to take ace throughout the mammal's lifetime.
Kimberly D, Tran +2 more
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Cytokines in Stem Cell Transplantation
Annals of the New York Academy of Sciences, 1995The use of cytokines in stem cell transplantation is still in the early stages of development. Efficacy has not been established consistently at the present time. When cytokines are employed in the treatment setting, they should be employed in a study setting evaluating whether there has been real patient benefit-palliation without compromise of ...
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Stem Cell Transplants at Childbirth
Stem Cell Reviews and Reports, 2009Autologous transplantation of stem cells is a natural phenomenon at birth in mammals via the umbilical cord. Here, we discuss that a delay in the cord clamping may increase stem cell supply to the baby, thereby allowing an innate stem cell therapy that can render acute benefits in the case of neonatal disease, as well as long-term benefits against age ...
Paul R, Sanberg +2 more
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Stem cell transplantation for thalassaemia
Reproductive BioMedicine Online, 2005Although improvements in conventional treatment have enhanced the prognosis of thalassaemia, stem cell transplantation remains the only cure. Over the last 2 decades, progress in preventive strategies, effective control of transplant related complications and development of new preparative regimens, have considerably improved the results of transplants
Javid, Gaziev, Guido, Lucarelli
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Hematopoietic Stem Cell Transplantation
Hospital Practice, 1993The isolation, purification, and in vitro expansion of the hematopoietic stem cell have allowed pretransplant immunologic and genetic manipulation. As a result, rapid allogeneic or autologous hematologic reconstitution with minimal graft-versus-host disease is possible in patients receiving high-dose chemotherapy.
S, Jagannath, B, Barlogie, G, Tricot
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Spermatogonial stem cell transplantation
Molecular and Cellular Endocrinology, 2000The development of the spermatogonial transplantation technique has given new impetus to research on spermatogonial stem cells. Possibilities opened by this technique include: (a) New ways to study fundamental aspects of spermatogenesis; (b) Generation of transgenic large domestic animals; (c) Protection of (young) male cancer patients from infertility
Izadyar, F. +4 more
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Stem cell transplantation for thalassemia
International Journal of Hematology, 2002Thalassemia, one of the most common genetic disorders, is considered to be a global problem. Several millions of the patients suffer from severe thalassemic diseases. Stem cell transplantation is currently the only curative therapy. Bone marrow transplantation offers a high probability of cure when performed in young children. There is a higher risk as
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Hematopoietic Stem-Cell Transplantation
New England Journal of Medicine, 2006Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically.
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Neural Transplantation and Stem Cells
2009Recent results have raised important questions on our ability to amplify stem cell populations in sufficient numbers as to be useful for therapy. Several reports have indicated that human stem cell populations harvested from the adult have low or undetectable telomerase levels, age in culture, and may not be propagated indefinitely.
Mahendra S, Rao, Mohan C, Vemuri
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In utero stem cell transplantation
Best Practice & Research Clinical Obstetrics & Gynaecology, 2004In utero haematopoietic cell transplantation (IUHCT) is a promising approach for the treatment of a variety of genetic disorders. The rationale is to take advantage of normal events during haematopoietic and immunological ontogeny to facilitate allogeneic haematopoietic engraftment.
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