Results 41 to 50 of about 236,518 (260)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Interdisciplinary Teacher Leadership, 2018 Four case studies of preservice teachers enrolled in a STEM-focused elementary teacher preparation program are used to document changes in mathematics and science teaching efficacy over the course of one academic year.
Margareta Maria Thomson +4 more
doaj +1 more source
Pre-Service Science Teachers’ Views of the Nature of STEM
Science Education International, 2020 Science, technology, engineering, and mathematics (STEM) education plays an important role in teaching and learning for the twenty-first century. Science teacher education is making great efforts to prepare STEM teachers for modern classroom practice and
Chatree Faikhamta
doaj +1 more source
Inclusive Instructional Practices: Course Design, Implementation, and Discourse
Frontiers in Education, 2021 As national efforts strive to make STEM more inclusive, it is important to identify instructional practices that maximize effective learning for all and provide students from different demographic and educational backgrounds equal opportunities to excel.
Shima Salehi +3 more
doaj +1 more source
Advancing STEM Education [PDF]
Chemical & Engineering News Archive, 2010 THIS IS A CRITICAL moment in our nation’s history, with great opportunities that require innovative solutions.
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Frontiers in Education, 2021 The COVID-19 pandemic has continued to impact every industry and test problem-solving capabilities and innovation across the board; education is no exception.
Demetri L. Morgan +3 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Journal of Microbiology & Biology EducationCommunity college transfer students face numerous challenges, including gaining access to undergraduate research experiences. In this Perspectives piece, we articulate the benefits of undergraduate research experiences for community college transfer ...
Emma C. Goodwin +3 more
doaj +1 more source