Results 41 to 50 of about 1,084,434 (304)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Advances in Physiology EducationMental health conditions can be highly relevant to a student’s academic journey, given the challenges, and sometimes strengths, they can provide. However, medical school applicants may be unsure about whether to reveal mental health conditions in their ...
Baylee A. Edwards +5 more
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Ricerche di Pedagogia e Didattica, 2021 In several international contexts, the teaching of technology in schools is changing, with the aim of better responding to the demands of young people, to new social and economic expectations, and the needs stemming from the rapid development of the ...
Damiano Felini
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Know Your Funders: A Guide to STEM Funding for Afterschool [PDF]
, 2012 The need for competency in science, technology, engineering and math (STEM) skills is not only increasingly important for success in the workforce but also to navigate the modern world and to make decisions that will inform public policy.
core
Education innovation through material innovation in primary education : the grow-it-yourself workshop [PDF]
, 2019 In recent years more STEM (Science, Technology, Engineering and Mathematics) topics have been incorporated in mainstream public education. Although the benefits of STEM instruction are broadly recognised in secondary school curricula, STEM topics in ...
Brosens, Lore, Emmanouil, Marina
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Frontiers in Education, 2023 IntroductionWhereas it is commonly assumed that in learning science, representational competence is a critical prerequisite for the acquisition of conceptual knowledge, comprehensive psychometric investigations of this assumption are rare. We undertake a
Peter Adriaan Edelsbrunner +1 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
HIV And The Need For A Voluntarist Approach [PDF]
, 1992 After a decade of fighting AIDS, the public health community has come to recognize that strategies to combat the infection must be premised on voluntarism and not on coercion.
Hansell, Esq., David A.
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Journal of NeuroinflammationTesticular tissues are highly vulnerable to oxidative stress and external insults due to their unique physiological microenvironment; thus, developing protective interventions is critical.
Liyong Liu +11 more
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