Results 81 to 90 of about 472,176 (299)

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan   +10 more
wiley   +1 more source

Aortic stenosis [PDF]

open access: yesEuropean Journal of Echocardiography, 2005
Aortic stenosis is a common finding at echocardiography. This review describes the assessment of the aortic valve, the left ventricle, and the rest of the heart. It discusses grading the stenosis including cases in which there are discrepancies between the different echocardiographic measurements.
openaire   +4 more sources

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

Post traumatic antral stenosis in a cat

open access: yesActa Veterinaria, 2019
The goal of this study was to report the first case of antral stenosis in a cat. We have described a clinical case of a 9 months old domestic shorthaired cat referred for persistent and refractory vomiting, anorexia and loss of weight.
Pelloni Angelo   +8 more
doaj   +1 more source

Transcatheter versus surgical aortic-valve replacement in high-risk patients. [PDF]

open access: yes, 2011
BACKGROUND: The use of transcatheter aortic-valve replacement has been shown to reduce mortality among high-risk patients with aortic stenosis who are not candidates for surgical replacement.
Makkar, Raj R   +47 more
core   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

open access: yesAdvanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu   +13 more
wiley   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita   +4 more
wiley   +1 more source

Effects of vessel dynamics and compliance on human right coronary artery hemodynamics with / without stenosis

open access: yesJournal of Biomechanical Science and Engineering, 2015
A computational study of effects of vessel dynamics and compliance on coronary artery hemodynamics with / without stenosis is presented. The coronary artery hemodynamics with stenosis has been a main subject as one of the major cardiovascular diseases ...
Takashi FUJIWARA   +5 more
doaj   +1 more source

Localization of endovascular tools in X-ray images using a motorized C-arm: visualization on HoloLens

open access: yesCurrent Directions in Biomedical Engineering, 2020
C-arms are medical devices widely used for image-guided minimally invasive endovascular procedures. This technology requires considerable experience for the physicians to position the C-arm to obtain X-ray images of the endovascular tools.
Chen Yenjung   +8 more
doaj   +1 more source

Renal artery stenosis-when to screen, what to stent? [PDF]

open access: yes, 2014
Renal artery stensosis (RAS) continues to be a problem for clinicians, with no clear consensus on how to investigate and assess the clinical significance of stenotic lesions and manage the findings.
Thomas M. MacDonald   +11 more
core   +1 more source

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