Results 131 to 140 of about 3,116,576 (279)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Folding-Based Electrochemical Aptasensor for the Single-Step Detection of the SARS-CoV-2 Spike Protein. [PDF]

ACS Appl Mater Interfaces, 2022
Curti F, Fortunati S, Knoll W, Giannetto M, Corradini R, Bertucci A, Careri M.   +6 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Can We Verify Step by Step for Incorrect Answer Detection?

Proceedings of the Thirty-ThirdInternational Joint Conference on Artificial Intelligence
Chain-of-Thought (CoT) prompting has marked a significant advancement in enhancing the reasoning capabilities of large language models (LLMs). Previous studies have developed various extensions of CoT, which focus primarily on enhancing end-task performance. In addition, there has been research on assessing the quality of reasoning chains in CoT.
Xin Xu, Shizhe Diao, Can Yang, Yang Wang
openaire   +2 more sources

Effectiveness, satisfaction and meaningfulness of a 6-step detection and prevention program for frail community-dwelling older adults: a mixed-method evaluation. [PDF]

BMC Geriatr, 2022
Dierckx E, Duppen D, Hoens S, Switsers L, Smetcoren AS, De Donder L, D-Scope.   +6 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Establishment and optimization of a system for the detection of Candida albicans based on enzymatic recombinase amplification and CRISPR/Cas12a system

Microbiology Spectrum
Invasive candidiasis is a fungal infection caused by various pathogenic yeasts, with Candida albicans as the predominant pathogen. Traditional culturing and identification methods for C.
Xiaotong Zeng, Qiuyang Jiang, Fo Yang, Qianlin Wu, Tingyao lyu, Qi Zhang, Jin Wang, Feng Li, Dayong Xu   +8 more
doaj   +1 more source

AutoStepfinder: A fast and automated step detection method for single-molecule analysis. [PDF]

Patterns (N Y), 2021
Loeff L, Kerssemakers JWJ, Joo C, Dekker C.   +3 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

On Unsupervised Multiclass Change Detection Using Dual-Polarimetric SAR Data

Remote Sensing
Change detection using SAR data has been an active topic in various applications. Because conventional change detection identifies signal changes in single-pol radar observations, they cannot separately detect different kinds of change associated with ...
Minhwa Kim, Seung-Jae Lee, Sang-Eun Park
doaj   +1 more source