Results 141 to 150 of about 198,471 (287)

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Multi-resolution tone mapping for high dynamic range medical ultrasound images. [PDF]

PLoS One
Vu TLN, Chandran V, Haberl C, Scherzer O, Binder J.   +4 more
europepmc   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Eating in the upside down: a critical look at the new U.S. dietary guidelines from a mediterranean perspective. [PDF]

Eat Weight Disord
Del Rio D.
europepmc   +1 more source

A Close Look at the Step Pyramid Restoration Project

A Close Look at the Step Pyramid Restoration Project
Saqqara is one of the most famous heritage sites and the Step Pyramid, the symbol of Saqqara, is the oldest stone building all over the world. It was built to be a tomb, where the first king from the third dynasty-Zoser-could be buried, by the famous ancient Egyptian architect Imhotep.
openaire  

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

TENG-Based Self-Powered Silent Speech Recognition Interface: from Assistive Communication to Immersive AR/VR Interaction. [PDF]

Nanomicro Lett
Lin S, Guo Y, Zeng X, Zhou X, Zhang Y, Li C, Wu C.   +6 more
europepmc   +1 more source

Harnessing Transformation of Metal‐Ligand Coordination in Dinuclear Ni(II)‐Schiff Base Coordination Polymer for Promoting Electrochemical Oxygen Evolution

Advanced Science, EarlyView.
Ni–Schiff base coordination polymer [Ni2(tmd)2]n was synthesized and applied to enhance alkaline OER by virtue of its transformation between 5‐ and 6‐coordinate Ni sites along with the spin state exchange. ABSTRACT One of the major challenges in overall water splitting is improving the sluggish kinetics of the anodic oxygen evolution reaction (OER ...
Ruei‐Hung Juang, Han‐Jung Li, Yu‐Chung Chang, Chieh‐Wei Chang, Ricky Yu‐Syun Fan, Kien Voon Kong, Jeng‐Lung Chen, Chia‐Shuo Hsu, Po‐Heng Lin, Chun‐Hong Kuo   +9 more
wiley   +1 more source

A comparative study of strain- and stress-based failure prediction methods in single-point incremental forming of Al/Ti two-layer sheets considering different strain paths. [PDF]

Sci Rep
Tayebi P, Meymand MM, Hashemi R.
europepmc   +1 more source