Results 61 to 70 of about 39,914 (257)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Novel 9-Steps Automatic AC Voltage Regulator based on Two Step-down Transformers [PDF]

International Journal of Electrical and Computer Engineering (IJECE), 2017
<p class="IEEEAbtract">A novel design and simulation results of 9-steps automatic AC voltage regulator based on one step-down transformer is presented in this paper. Avoiding the problem of surge at the AC load during controlling jump steps is done through the proposed design. Accurate and smooth controlling function is achieved as well.
openaire   +1 more source

Real Time Performance Comparison of Buck Converter Circuit Controlled By Discrete Time PID, LQR and SMC Controllers in Continuous-Current Mode

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2019
In this study, a DC-DC buckconverter circuit which is used to get direct voltage by decreasing the sourcevoltage is researched. Firstly mathematical model for a DC-DC buck convertercircuit is obtained and critical inductance value is calculated to make ...
Ömer Özdemir, İrfan Yazıcı
doaj   +1 more source

REGULATORY CHARACTERISTICS OF THE STEP-DOWN SWITCHING REGULATOR WHICH CHARGES THE BATTERY FROM THE SOLAR BATTERY

Electrical engineering & Electromechanics, 2020
Problem. An important element of autonomous power sources, built on the basis of solar batteries, is a battery, operating in a buffer mode. To extend the period of its use, it is necessary to ensure the appropriate modes of its charging and discharging ...
V. Ya. Romashko, L. M. Batrak, O. O. Abakumova   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modeling of virtual synchronous controlled-DFIG considering stator voltage control dynamics for transient stability analysis

International Journal of Electrical Power & Energy Systems
Transient stability of virtual synchronous controlled (VSynC) equipment is usually analyzed without considering the dynamics of the AC voltage controller.
Xiangkun Meng, Shiying Ma, Chao Zheng
doaj   +1 more source