Results 61 to 70 of about 15,977 (241)

Stepping stones and access holidays: the fallacies of regulatory micro-management [PDF]

Good intentions are no substitute for sound economic regulation. Using the ‘in-vestment ladder’ as the stick and access holidays as the carrot is hardly an ef-fective way to generate competition. On the contrary, this approach creates a regulatory spiral.
Knieps, Günter, Zenhäusern, Patrick
core  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Scientific CCD technology at JPL [PDF]

Charge-coupled devices (CCD's) were recognized for their potential as an imaging technology almost immediately following their conception in 1970. Twenty years later, they are firmly established as the technology of choice for visible imaging.
Collins, S. A., Fossum, E. R., Janesick, J.   +2 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Effectiveness of the Stepping Stones Triple P parent training as an additional intervention in the treatment of Autism-Spectrum-Disorders - Effects on parenting behavior

, 2017
This study explored the effect of the Stepping Stones Triple P (SSTP) group parent training on parent-child interactions in families of children with Autism-Spectrum- Disorders (ASD) with a focus on parenting behavior. Significant aspects of parent-child interactions and especially parenting are the concrete parenting behavior, parental selfefficacy ...
Schrott, Bastian, Kamp-Becker, Inge (Prof. Dr.)   +1 more
openaire   +2 more sources

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Solar‐Driven Ammonia Synthesis From Nitrate Reduction Paired With CO2 Capture for Sustainable Agriculture via a Robust CuPd Heterojunction

Angewandte Chemie, EarlyView.
Laser‐assisted synthesis of CuPd amorphous/crystalline heterojunction demonstrates >80% Faradaic efficiency for nitrate‐to‐ammonia electroreduction across wide potential windows. The integrated solar‐powered electrolyzer achieves 6% solar‐to‐ammonia energy efficiency at 0.4 sun, 6–20 mg h−1 CO2 capture rate, and stability exceeding 100 h.
Weihua Guo, Xiaofeng Huang, Yangbo Ma, Yun Song, Zihao Li, Qiang Zhang, Yinger Xin, Jianjun Su, Mingming He, Ruixuan Wang, Rui Xue, Xing Li, Shibo Xi, Jian Wang, Shenlong Zhao, Siwei Zhang, Ben Zhong Tang, Alex K. Y. Jen, Ruquan Ye   +18 more
wiley   +2 more sources

The role of social identity and self-efficacy in predicting service providers’ use of Stepping Stones Triple P following training

Children and Youth Services Review
Background: Identifying factors that may contribute to the use of programs following the completion of training by practitioners is of practical and theoretical importance. Aim: This study examined the role of social identity and self-efficacy in contributing to the delivery of an evidence-based parenting program. Methods and Procedures: A sample of 63
Cassandra L. Tellegen, Martha Schoch, Julie Hodges, Kim Peters, Matthew R. Sanders, Bruce Tonge, Stewart Einfeld, Kate Sofronoff, Kylie M. Gray, Patricia Howlin, Eric Emerson, Jo Arciuli, Lauren Rice, Sian Horstead, Kristina Clarke, Louise Bezzina, Holly Evans, Ellaina Andersson, Zyra McAuliffe, Kaaran Haas, Eva Louie, Fiona Hoath, Sheena Worrall, Lucile Stace, Natalie Silove, Pauline Kostelas, Jodie Caruana, David Dossetor, Luis Salvador-Carulla, Kevin Henderson, Kathryne Phillis, Cassandra Rotolone, Tania Henry, Babak Panahi, Anagha Aery, Sharon Hinton, Donna-Marie Thompson, Berthine Ommensen, Trevor Mazzucchelli, John Taffe, Nan Hu, Ross Boland, Rachael Knott, Gemma O'Hagan, Oriel Rose, Fionnuala Shortt, Danyelle Cawood, Rebecca Blackmore, Emily Wallman, Caroline Keating, Samantha Teague, Rosalie Viney, Stephen Goodall, Sheena Arora   +53 more
openaire   +2 more sources

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Predicting Treatment Success in Child and Parent Therapy Among Families in Poverty [PDF]

, 2016
Behavior problems are prevalent in young children and those living in poverty are at increased risk for stable, high-intensity behavioral problems. Research has demonstrated that participation in child and parent therapy (CPT) programs significantly ...
Fox, Robert A., Harris, Sara E., Mattek, Ryan   +2 more
core   +1 more source