Results 211 to 220 of about 8,034,760 (273)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The active ingredients: physical activity features linked to healthy brain aging. [PDF]

Alzheimers Res Ther
Cadwallader CJ, Pinheiro-Chagas P, Saloner R, Fenton L, VandeBunte AM, Lin M, Pham A, Chen C, Diaz VE, Olzinski M, Licata S, Callies L, Lo C, Buxton J, Cobigo Y, Rabinovici G, Kramer JH, Casaletto KB, Paolillo EW.   +18 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

FIRST STEPS TO MARKETING A SMALL BUSINESS [PDF]

, 2013
Slyusar, R.
core  

Implicit sub-stepping scheme for critical state soil models. [PDF]

Eng Comput
Bui HG, Niníc J, Meschke G.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Daily step recommendation adherence and peak bone mineral density among female nurses: A cross-sectional study. [PDF]

Medicine (Baltimore)
Xu G, Feng S, Wu Y, Ai X, Zhang Y.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal Analysis of Variations in Daily Step Counts and Long-Term Implications of COVID-19 Waves and Restriction Phases in Qatar's Step Into Health Program: Mixed Methods Study.

JMIR Public Health Surveill
Majed L, Sayegh S, Dalansi F, Al-Mohannadi AS, Cardinale M, Farooq A.   +5 more
europepmc   +1 more source

Criterion Validation for Step Count and Distance Covered During the 6-Minute Walk Test Using a Low-Cost, Commercially Available Activity Monitor. [PDF]

Mayo Clin Proc Digit Health
Babu AS, Abraham AA, Mathew BM, Malpe SM, Satyamurthy A.   +4 more
europepmc   +1 more source