Results 251 to 260 of about 63,316 (301)
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STEREOCHEMISTRY IN ANAESTHESIA
Clinical and Experimental Pharmacology and Physiology, 1997SUMMARY1. Interest in the pharmacokinetic and pharmacodynamic properties of the enantiomers of chiral drugs has greatly increased in recent years. This is particularly so for agents used in anaesthesia.2. Chiral compounds are those that can exist in two non‐superimposable forms. Each form is termed an enantiomer or stereoisomer.
D A, Sidebotham, S A, Schug
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The stereochemistry of pinidine
Tetrahedron, 1965Abstract The stereochemistry of pinidine, a piperidine alkaloid from Pinus sabiniana, was established by chemical and spectroscopic methods as 2-(R)-methyl-6-(R)-(2-trans-propenyl)-piperidine (XXI). Some interesting rearrangements which occurred during degradative studies are discussed, and the configuration of pinidine is compared with that of ...
R K, Hill, T H, Chan, J A, Joule
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Stereochemistry and Bioequivalence
The Journal of Clinical Pharmacology, 1992Despite the fact that many important drugs are chiral, for a variety of reasons they are marketed as racemates (i.e., an equal proportion of two enantiomers). Although enantiomers of racemic drugs often differ from one another in their pharmacodynamic and pharmacokinetic properties, bioequivalence assessments are made using nonstereospecific assays ...
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The synthesis and stereochemistry of desacetoxymatricarin and the stereochemistry of matricarin
Tetrahedron, 1969Abstract Desacetoxymatricarin (IV), a sesquiterpene lactone found in the genus Artemisia and in the form of 8-hydroxy and acetoxy derivatives in the genus Achillea, has been synthesized from α-santonin by a sequence that allows assignment of the full stereochemistry. The stereochemistry of matricarin (V) has also been determined.
E.H. White, S. Eguchi, J.N. Marx
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International Journal of Peptide and Protein Research, 1988
This review article, based on a lecture delivered in Madras in 1985, is an account of the author's experience in the working out of the molecular structure and conformation of the collagen triple‐helix over the years 1952–78. It starts with the first proposal of the correct triple‐helix in 1954, but with three residues per turn, which was later refined
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This review article, based on a lecture delivered in Madras in 1985, is an account of the author's experience in the working out of the molecular structure and conformation of the collagen triple‐helix over the years 1952–78. It starts with the first proposal of the correct triple‐helix in 1954, but with three residues per turn, which was later refined
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Accounts of Chemical Research, 2017
The relationship between fundamental and applied is often uneasy, particularly in modern political climates. A familiar political view, aimed negatively at the scientific community, is that the former is a waste of money whereas the latter gives value for investment.
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The relationship between fundamental and applied is often uneasy, particularly in modern political climates. A familiar political view, aimed negatively at the scientific community, is that the former is a waste of money whereas the latter gives value for investment.
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2020
This short chapter is really just to set the scene for the rest of the book, highlighting the importance of stereochemistry and the approaches we can use to study the topic. Don't worry if the new material appears daunting at this point. We'll go through it slowly in the relevant chapters.
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This short chapter is really just to set the scene for the rest of the book, highlighting the importance of stereochemistry and the approaches we can use to study the topic. Don't worry if the new material appears daunting at this point. We'll go through it slowly in the relevant chapters.
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2012
This chapter reviews stereochemistry. It begins by differentiating between enantiomers and chiral compounds. Two structures that are not identical but are mirror images of each other are called enantiomers. Structures that are not superimposable on their mirror image, and can therefore exist as two enantiomers, are called chiral.
Jonathan Clayden +2 more
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This chapter reviews stereochemistry. It begins by differentiating between enantiomers and chiral compounds. Two structures that are not identical but are mirror images of each other are called enantiomers. Structures that are not superimposable on their mirror image, and can therefore exist as two enantiomers, are called chiral.
Jonathan Clayden +2 more
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