Results 231 to 240 of about 63,316 (301)

Omega‐3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Álex Pérez‐Sánchez, Mireia Garcia‐Viloca, Àngels González‐Lafont, José M. Lluch   +3 more
wiley   +1 more source

DP5 without DFT: uncertainty-calibrated graph neural net accelerates structure confirmation <i>via</i> NMR. [PDF]

Chem Sci
Kotlyarov R, Howarth A, Goodman JM.
europepmc   +1 more source

The Biosynthesis and Functions of Flavonoids: Recent Advances From Studies Across Land Plant Diversity

Journal of the Royal Society of New Zealand, Volume 56, Issue 3, June 2026.
Over the last decade there have been significant advances in genome sequencing and model species development for ferns, lycophytes, and the bryophyte lineages—mosses, liverworts, and hornworts. This has facilitated research on the biosynthesis and function of flavonoids in these non‐seed land‐plant lineages.
Kevin M. Davies, Nick W. Albert, Rebecca M. Yorker, Kathy E. Schwinn, Yanfei Zhou   +4 more
wiley   +1 more source

Stereoselective synthesis of 1'-α-cyano carbocyclic pyrimidine nucleoside analogs <i>via</i> a chelation-controlled 1'-α-hydroxymethylation strategy.

Org Biomol Chem
Biteau NG, Kasthuri M, Patel D, De R, Schinazi RF, Amblard F.   +5 more
europepmc   +1 more source

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues. [PDF]

Angew Chem Int Ed Engl
George MRP, Elsadek LA, Deering M, de Almeida LC, Tyler JL, Noble A, Paul VJ, Luesch H, Butts CP, Aggarwal VK.   +9 more
europepmc   +1 more source

Kineochelins—A New Group of Siderophores From an Antarctic Bacterium

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Genome‐guided analysis of an Antarctic Actinokineospora strain led to the discovery of kineochelins, a new group of siderophores involved in iron sequestration and microbial competition. Kineochelin production inhibits co‐occurring bacteria and clinically relevant yeasts, highlighting Antarctic microorganisms as promising sources of bioactive natural ...
Stanislava Kralova, Peter Spacek, Johannes Gafriller, Matej Bezdicek, Viktoria Medvedcova, Joana Séneca, Jay Osvatic, Ulrike Grienke, Thomas Rattei, Olga N. Sekurova, Sergey B. Zotchev, Martin Zehl, Alexander Loy   +12 more
wiley   +1 more source

Author Correction: Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide. [PDF]

Nat Commun
Kongstad KT, Hansen NL, Kjaerulff L, Heck QK, Forman V, Staerk D, Møller BL, Andersen-Ranberg J.   +7 more
europepmc   +1 more source

Drivers of strigolactone diversity: P450s in strigolactone biosynthesis

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1635-1652, June 2026.
This review summarizes the discovery and functional identification of cytochrome P450 in strigolactone biosynthesis, classifies and summarizes the members discovered so far, clarifies their biological significance, discusses the technology of strigolactone synthesis research, and finally describes some problems in strigolactone research and potential ...
Changbin Niu, Harro J. Bouwmeester, Changsheng Li   +2 more
wiley   +1 more source

Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues. [PDF]

ACS Med Chem Lett
Elhalawaty EA, Alseedy HA, Woodland JG, Wicht KJ, Swart T, Rangel GW, Hoppe HC, Chibale K, Llinás M, Abadi AH, Ahmed NS.   +10 more
europepmc   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3708-3722, June 2026.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source