Results 81 to 90 of about 21,877 (199)

Chronic alcohol consumption and withdrawal do not induce cell death in the suprachiasmatic nucleus, but lead to irreversible depression of peptide immunoreactivity and mRNA levels [PDF]

, 1997
There is evidence that chronic ethanol treatment (CET) disrupts the biological rhythms of various brain functions and behaviors. Because the suprachiasmatic nucleus (SCN) is widely recognized as the dominant pacemaker of the circadian system, we have ...
Almeida, OFX, Andrade, JP, Lieberman, AR, Madeira, MD, Paula-Barbosa, MM, Sousa, N   +5 more
core   +1 more source

SIX2‐Mediated Microglial M2 Polarization and Exosomal miR‐3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
We found that SIX2 directly upregulates DDIT4 expression by binding to its promoter region, leading to the suppression of mTOR signaling and subsequent activation of autophagy. This autophagy induction facilitates the transition of microglial cells from a pro‐inflammatory M1 phenotype to the neuroprotective M2 phenotype.
Jia‐shuo Kan, Xia‐yin Cao, Yu‐xin Ye, Xin‐xing Huang, Guo‐jing Sun, Jin Gao   +5 more
wiley   +1 more source

Volume and surface changes in vero cell and its nucleus after infection with measles virus: a stereological study

Microbiology Research, 2011
Measles virus has no or indistinctive cytopathic effects (CPE) in cell couture system. Employment of some detecting methods like plaque assay or stereologic experiments, as a method of detecting of viral infection in the cells would be applicable.
Ali Noorafshan, Mohammad Motamedifar, Saied Karbalay-Doust   +2 more
doaj   +1 more source

STEREOLOGICAL ANALYSIS OF SHAPE

Image Analysis & Stereology, 2011
This paper concerns the problem of making stereological inference about the shape variability in a population of spatial particles. Under rotational invariance the shape variability can be estimated from central planar sections through the particles. A simple, but flexible, parametric model for rotation invariant spatial particles is suggested.
Hobolth, Asger, Jensen, Eva Bjørn Vedel
openaire   +3 more sources

Inhibitory GABAergic Neuron Loss due to Oxidative Damage During Ex Vivo Acute Brain Slice Preparation Influences Genesis and Dynamics of Epileptiform Activity

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ex vivo brain slice preparation is a popular technique in neuroscience research with many variations in preparation method. We compared two popular variations in brain slice preparation and found that the choice of brain slice preparation technique significantly affects the viability of neuronal preparation.
Felix Chan, Anupam Hazra, Ashan Jayasekera, Katherine Huang, Shuna Whyte, Leolie Telford‐Cooke, Kamilah Lakhani, Xiaomeng Li, Rebecca Shields, Angeline Kosim, Darwin Su, Carol Murray, Mark O. Cunningham   +12 more
wiley   +1 more source

Neurostereology Protocol for Unbiased Quantification of Neuronal Injury and Neurodegeneration

Frontiers in Aging Neuroscience, 2015
Neuronal injury and neurodegeneration are the hallmark pathologies in a variety of neurological conditions such as epilepsy, stroke, traumatic brain injury, Parkinson’s disease and Alzheimer’s disease.
Victoria M Golub, Jonathan eBrewer, Xin eWu, Ramkumar eKuruba, Jenessa eShort, Maunica eManchi, Megan eSwonke, Iyan eYounus, Samba eReddy   +8 more
doaj   +1 more source

Robot‐Assisted Automated Serial‐Sectioning and Imaging for 3D Microstructural Investigations

Advanced Engineering Materials, Volume 28, Issue 2, 21 January 2026.
A fully automated 3D microstructure characterization platform provides new insights into materials. This robot‐assisted system performs serial‐sectioning, etching, and optical imaging to generate large‐volume 3D reconstructions with submicron resolution.
Michael Moschetti, Anton Lemiasheuski, Evgenia Bajer, Ilja Porohovoj, Artur Göbel, Anja Pfennig, Dirk Bettge, Robert Maaß   +7 more
wiley   +1 more source

Flavonoids of Phoenix dactylifera L. ameliorates mercury-toxicity on the kidney of Wistar rats. A biochemical, morphological and molecular approach

Pharmacological Research - Modern Chinese Medicine
Introduction: One of the primary target organs of mercury toxicity is the kidney. Inorganic mercury such as mercuric chloride (HgCl2) significantly damages the kidney. Phoenix dactylifera has been documented to possess several pharmacological activities.
M.G. Abubakar, A.N. Agbon, S.A. Musa, W.O. Hamman, S.B. Oladele   +4 more
doaj   +1 more source

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source

On the Ambartzumian-Pleijel identity in hyperbolic geometry [PDF]

, 2014
We describe a hyperbolic version of the Ambartzumian-Pleijel identity. We use this identity to prove the hyperbolic Crofton formula and the hyperbolic isoperimetric inequality.
Binbin, Xu
core