Results 111 to 120 of about 22,435 (264)

Breathing irregularities and postnatal hypoxaemia in an experimental model of essential hypertension

The Journal of Physiology, EarlyView.
Abstract figure legend Neonatal spontaneously hypertensive rats (SHRs) exhibit inherent respiratory dysfunction in early life, including oscillatory breathing patterns and apnoeic events that cause oxygen desaturation and brain hypoxia, in addition to an impaired hypoxic ventilatory response.
Beatriz N. Vieira, Letícia R. Mendes, Sarah G. Mariano, Isabela P. Leirão, Emilson D. Pereira‐Junior, Milede H. Saraiva Paes, Pedro L. Katayama, Daniel B. Zoccal   +7 more
wiley   +1 more source

Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner, Véronique Dehlinger, Patrick Rodriguez, Kerstin Fabbri, Yvan Varisco, Matteo Pigni, Alessandra Lovison, Lucas Münzenmaier, Kasia Piorkowska, Aline Fuchs, Nadine Ait‐Bouziad, Nicolas Fournier, Sandra Jepaul, Jérôme Molette, Emanuele Gabellieri, Vincent Darmency, Sonia Poli, Andrea Pfeifer, Marie Kosco‐Vilbois, Francesca Capotosti   +19 more
wiley   +1 more source

Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Early‐life exposure to general anesthetics has been linked to long‐term neurodevelopmental risks, yet the underlying mechanisms remain unclear. Using a mouse model, we show that neonatal isoflurane exposure at Postnatal Day 7 leads to age‐dependent behavioral alterations, changes in cortical neuronal abundance and layer‐specific neuronal ...
Ke Chen, Mengdi Xia, Changhong Li, Zhenhua Ren, Xiaohui Li   +4 more
wiley   +1 more source

MRI guided stereotactic ventrointermediate thalamotomy for writer's cramp: two cases report and literature review

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Objective To explore the methods and curative effect of stereotactic surgery for treating writer's cramp (WC). Methods and Results Two patients with writer's cramp (tremor type) underwent MRI guided stereotactic ventrointermediate (Vim) thalamotomy on
Chao-shi NIU, Wan-hai DING, Wan-xiang NIU, Peng CHEN, Chi XIONG   +4 more
doaj  

The Human Dorsolateral Prefrontal Cortex in Pain and Pain Modulation: A Review and Activation‐Likelihood Estimation Approach

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background The dorsolateral prefrontal cortex (dlPFC) has become a cornerstone of pain neuroscience, believed critically involved in processing acute and chronic pain, as well as in pain modulation. The dlPFC is thought to balance sensory perception with the cognitive appraisal of noxious stimuli.
Lewis S. Crawford, Damien C. Boorman, James W. M. Kang, Allan Peng, Kevin A. Keay, Luke A. Henderson   +5 more
wiley   +1 more source

Dosimetric comparison of irradiation techniques of intracranial stereotaxic radiotherapy for multiple brain metastases

, 2022
Die vorliegende Arbeit beschäftigt sich mit der intrakraniellen stereotaktischen Strahlentherapie bei der Behandlung von multiplen Hirnmetastasen. Ziel ist es, die Bestrahlungstechniken hinsichtlich des Zielvolumens (Planning Target Volume [PTV]) und der
Nowak, Jessica
core  

Dissociation Between Hemodynamic and Metabolic Responses to Chemogenetic Modulation of Astrocytes in Mouse Visual Cortex

Glia, Volume 74, Issue 7, July 2026.
Chemogenetic astrocytic modulation in mouse visual cortex showed no local glucose uptake change (PET) but enhanced hyperemia and vasomotion (fUSi), revealing a local dissociation with a negative correlation between metabolic and hemodynamic signals.
Mickaël Pereira, Benjamin Vidal, Marco Valdebenito, Fatima Cheataini, Caroline Bouillot, Louis Vidal, Liam Nestor, Dimitri De Bundel, Ilse Smolders, Marine Droguerre, Luc Zimmer   +10 more
wiley   +1 more source

A new in silico model to precisely design focused ultrasound brain therapies

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Focused ultrasound (FUS) combined with microbubbles enables transient and noninvasive blood–brain barrier (BBB) opening, facilitating targeted drug delivery. However, accurate treatment planning remains difficult due to inter‐patient anatomical variability and the common assumption in simulations that brain tissues behave like water.
Allegra Conti, Marta Grossi, Patricia Cardoso De Andrade, Andrea Duggento, Nicola Toschi   +4 more
wiley   +1 more source

Stereotaxic surgery in the treatment of brain tumors

Acta Médica del Centro, 2014
In recent years Neurosurgery Specialists have seen a dramatic improvement in imaging techniques, which has led, in parallel, to the resurgence of stereotactic techniques.
Juan Guillermo Trigo Naranjo, Jorge Abel Anoceto Díaz   +1 more
doaj  

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source