Results 121 to 130 of about 38,147 (287)
Evaluating techniques in tissue clarification using CLARITY imaging and investigating where sodium is sensed in the body [PDF]
, 2016 OBJECTIVE: Previous studies have shown the significant contribution of sympathoinhibition in response to sodium loading to prevent increases in mean arterial blood pressure in salt resistant phenotypes.
Neal, Christopher Matthew
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Movement Disorders, EarlyView.Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo +6 more
wiley +1 more source
Brain Pathology, EarlyView.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Objective To explore the methods and curative effect of stereotactic surgery for treating writer's cramp (WC). Methods and Results Two patients with writer's cramp (tremor type) underwent MRI guided stereotactic ventrointermediate (Vim) thalamotomy on
Chao-shi NIU +4 more
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British Journal of Pharmacology, EarlyView.Background and Purpose Ketamine consists of two enantiomers, (R)‐ketamine and (S)‐ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)‐enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)‐ketamine.
Szabolcs Koncz +4 more
wiley +1 more source
Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty. [PDF]
, 2019 The subjective sense of certainty, or confidence, in ambiguous sensory cues can alter the interpretation of reward feedback and facilitate learning. We trained rats to report the orientation of ambiguous visual stimuli according to a spatial stimulus ...
Hart, EE +7 more
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Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation
Cell Proliferation, EarlyView.During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu +10 more
wiley +1 more source
Assessing the risk of central post-stroke pain of thalamic origin by lesion mapping [PDF]
, 2017 Central post-stroke pain of thalamic origin is an extremely distressing and often refractory disorder. There are no well-established predictors for pain development after thalamic stroke, and the role of different thalamic nuclei is unclear.
Andreou, Anna P. +9 more
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Mitochondrial control of ciliary gene expression and structure in striatal neurons
The Journal of Physiology, EarlyView.Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen +5 more
wiley +1 more source
Stereotaxic surgery in the treatment of brain tumors
Acta Médica del Centro, 2014 In recent years Neurosurgery Specialists have seen a dramatic improvement in imaging techniques, which has led, in parallel, to the resurgence of stereotactic techniques.
Juan Guillermo Trigo Naranjo +1 more
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