Results 141 to 150 of about 22,435 (264)

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia.
Keying Chen, Emma Pineau, Margaret Koletar, Andrea Trevisiol, Jack Simiao He, Mary Hill, Maged Goubran, John Sled, JoAnne McLaurin, Bojana Stefanovic   +9 more
wiley   +1 more source

Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Sleep disruption is an early feature of Alzheimer's disease (AD), but the cellular mechanisms linking amyloid pathology to sleep loss remain unclear. METHODS Electroencephalography/electromyography (EEG/EMG) recordings, quantitative EEG analysis, and sleep deprivation were performed in APPswe/PSEN1dE9 (APP/PS1) mice at different ...
Nicholas J. Constantino, Riley E. Irmen, Matthew J. Lanning, Sierra M. Turner, Clair C. Ashley, Caitlin M. Carroll, Evan M. Neary, Dave Rubinow, J. Andy Snipes, Shannon L. Macauley   +9 more
wiley   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, Volume 99, Issue 6, Page 1571-1588, June 2026.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Hippocampal Glutamatergic Hyperactivation Mediates High‐Loading Intensity of Exercise‐Induced Cognitive Deficits Via HPC‐mPFC Circuit Dysfunction

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
High‐loading intensity of exercise (HLIE) disrupts HPC‐mPFC connectivity and hippocampal activity‐related transcriptomes, mediating cognitive deficits via glutamatergic neuron hyperactivation. Hippocampal glutamatergic neuron hyperactivation drives HLIE‐induced cognitive deficits, while targeted chemogenetic inhibition partly rescues cognitive function.
Qian Bai, Le Wang, Hedong Lang, Hongtao Yu, Xiaolei Wang, Jian Wang, Jundong Zhu, Ka Chen, Mantian Mi   +8 more
wiley   +1 more source

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

Protocol for the precise activation of intradental neurons in mice via electrical stimulation. [PDF]

STAR Protoc
Wan S, Ronan EA, Jha A, Gandhi AR, Constantinescu BSC, Pipe KP, Emrick JJ.   +6 more
europepmc   +1 more source

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus–Dentate Gyrus Circuit

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Electroacupuncture at ST36 alleviates cognitive deficits and restores hippocampal synaptic plasticity in VCI rats by activating the SuMGlu‐DG circuit. This study identifies the SuMGlu‐DG circuit as an essential mediator for the therapeutic and neuroprotective effects of acupuncture in vascular‐induced cognitive decline.
Fang Wan, Lu Wang, Qing‐Yong Wang, Jing‐Wen Yang, Cun‐Zhi Liu   +4 more
wiley   +1 more source

Establishment of a novel rat model of chronic subdural hematoma: Recapitulating human pathological features through triple-component induction. [PDF]

IBRO Neurosci Rep
Lu Q, Zhang R, Tan Y, Xu Y, Zhang Y, Zhao R, Li Q, Yang P, Liu J, Zuo Q.   +9 more
europepmc   +1 more source

1 Hz Low‐Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon‐γ Signaling‐Dependent Microglial Synaptic Phagocytosis in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
In a mouse model of recurrent seizures, 1 Hz rTMS exerted neuroprotective effects by enhancing IFN‐γ‐dependent STAT2 activation in microglia and reducing CADM1/2/3 expression, thereby limiting excessive synaptic phagocytosis. Notably, co‐treatment with a neutralizing antibody against IFN‐γ abolished the 1 Hz rTMS‐induced STAT2 activation and the ...
Donghui Lin, Duan Wang, Nong Xiao
wiley   +1 more source