Results 181 to 190 of about 265,264 (294)

DEAD‐Box Helicase 6 Blockade in Brain‐Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity

open access: yesMedComm, Volume 6, Issue 5, May 2025.
We identified four proteins (DSP, JUP, HRNR, and DDX6) that bind to amyloid‐beta (Aβ) oligomers derived from the brains of Alzheimer's disease (AD) patients. Among these four proteins, only the blockade of DEAD‐box helicase 6 (DDX6) in AD brain‐derived Aβ oligomers attenuated their neurotoxicity.
Xiaoxu Wang   +10 more
wiley   +1 more source

Prenatal Intake of High Multivitamins or Folic Acid With or Without Choline Contributes to Gut Microbiota‐Associated Dysregulation of Serotonin in Offspring

open access: yesMolecular Nutrition &Food Research, Volume 69, Issue 9, May 2025.
Consuming too much vitamins including folic acid or not enough choline during pregnancy can disturb the gut–brain serotonergic system in adult offspring. Lactococcus, Ruminococcus, Bacteroides, and Oscillospira were associated with altered serotonergic expression and function in male and female offspring, highlighting unique gut microbiota patterns ...
Jianzhang Dong   +5 more
wiley   +1 more source

Intracranial glioma xenograft model rapidly reestablishes blood–brain barrier integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography and contrast agents [PDF]

open access: yes, 2020
Achilefu, Samuel   +9 more
core   +1 more source

Neuronal activity modulates the expression of secretagogin, a Ca2+ sensor protein, during mammalian forebrain development

open access: yesActa Physiologica, Volume 241, Issue 5, May 2025.
Abstract Aim Because of their stable expression, some EF‐hand Ca2+‐binding proteins are broadly used as histochemical markers of neurons in the nervous system. Secretagogin is a member of “neuron‐specific” Ca2+‐sensor proteins, yet variations in its expression due, chiefly, to neuronal activity remain ambiguous.
János Hanics   +7 more
wiley   +1 more source

DCC in the cerebral cortex is required for cognitive functions in mouse

open access: yesBrain Pathology, Volume 35, Issue 3, May 2025.
Abstract Schizophrenia (SZ) is a highly heritable mental disorder, and genome‐wide association studies have identified the association between deleted in colorectal cancer (DCC) and SZ. Previous study has shown a lowered expression of DCC in the cerebral cortex of SZ patient.
Yun‐Qing Hu   +9 more
wiley   +1 more source

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