Results 81 to 90 of about 22,435 (264)

Preganglionic innervation of the pancreas islet cells in the rat [PDF]

, 1984
The position and number of preganglionic somata innervating the insulin-secreting β-cells of the endocrine pancreas were investigated in Wistar rats.
Steffens, A.B.,, Luiten, P. G. M., TERHORST, GJ, Koopmans, S. J., Koopmans, S.J.,, Luiten, P.G.M.,, ter Horst, G. J., Rietberg, M., KOOPMANS, SJ, LUITEN, PGM, Horst, G.J. ter,, Rietberg, M.,, RIETBERG, M, STEFFENS, AB, Steffens, A. B.   +14 more
core   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Increasing the effectiveness of intracerebral injections in adult and neonatal mice: a neurosurgical point of view [PDF]

, 2015
International audienceIntracerebral injections of tracers or viral constructs in rodents are now commonly used in the neurosciences and must be executed perfectly.
Miles, Richard, Nassar, Mérie, Clemenceau, Stéphane, Mathon, Bertrand, Simonnet, Jean, Le Duigou, Caroline, Fricker, Desdemona   +6 more
core   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Surgical treatment of particular facial pain syndromes (Sindromi dolorose facciali trattabili con la chirurgia)

Pathos, 2013
The authors list the facial pain syndromes not responsive to pharmacological therapies that can be treated with surgical procedures specific for the different syndromes.
Giovanni Broggi, MD, Michele Rizzi, MD, Giuseppe Messina, MD, Angelo Franzini, MD   +3 more
doaj  

Stereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors

, 2016
International audienceGlioblastoma multiforme (GBM) represents the most frequent and deadliest primary brain tumor.Aggressive treatment still fails to eliminate deep brain infiltrative and highly resistant tumor cells.Human Vg9Vd2 T cells, the major ...
Robard, Myriam, Oliver, Lisa, Vallette, François, M., Jarry, Ulrich, Chauvin, Cynthia, Joalland, Noémie, Pecqueur, Claire, Vallette, François,, Léger, Alexandra, Bonneville, Marc, Scotet, Emmanuel, Minault, Sandrine, Vié, Henri   +12 more
core   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Topography of acute stroke in a sample of 439 right brain damaged patients

NeuroImage: Clinical, 2016
Knowledge of the typical lesion topography and volumetry is important for clinical stroke diagnosis as well as for anatomo-behavioral lesion mapping analyses.
Christoph Sperber, Hans-Otto Karnath
doaj   +1 more source

A Method for Precision Surgical Implantation and Probe Insertion in Sprague-Dawley Rat Brain

, 2020
Motorized stereotaxic is an advanced tool for surgery and implantation of cannula and electrodes in neuroscience. Stereotaxic surgery and implantation has become increasingly important tool, applied in many experiments.
Wan Raihana Wan Aasim, Asma Ulhusna Shaimi, Hasmah Abdullah, Wan Amir Nizam Wan A hmad   +3 more
core