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Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Ligand-Enabled Hydrohydrazidation of Alkynes Catalyzed by Unsymmetrical Gold(I)-Thiazol-2-ylidenes. [PDF]
Ma S +7 more
europepmc +1 more source
Design, Synthesis, and Biological Evaluation of Selective CDK4/9 Inhibitors. [PDF]
Li S +6 more
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Remote Stereocontrol in Aryl/Alkyl C-H Insertion Reactions of Rhodium Carbenes: Assembly of Pseudorigidols A and B. [PDF]
Ung L +4 more
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Cyclometalated Ir(iii) complexes bridged by µ-OH and µ-3,5-bis(4-methoxyphenyl)-pyrazole ligands. [PDF]
Mausami +8 more
europepmc +1 more source
Entanglement-Mediated Dispersion of Lignin Nanoparticles in PVA Networks for Transparent and Tough Bio-Composites. [PDF]
Lee IJ, Kim SY.
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Steric effects in alkylpyrimidines
Recueil des Travaux Chimiques des Pays-Bas, 1978AbstractTreatment of solutions of 4,6‐dimethylpyrimidine and 4,6‐di‐t‐butylpyrimidine in acid with aliphatic acids (RCO2H) in the presence of silver nitrate and ammonium peroxydisulfate gave the 2‐R‐4,6‐dimethyl‐ and 2‐R‐4,6‐di‐t‐butylpyrimidines (R = C2H5, i‐C3H7, t‐C4H9). Ths pKa values of these compounds were measured.
van der Plas, H.C., Koudijs, A.
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Tetrahedron, 1980
The steric effect of alkyl groups as characterized by the revised Taft E's parameter is analysed using an approach based on the DARC topological system and its PELCO correlation method. This approach involves an analysis of the systemativ variation of E's in a topological dequencing of alkyl groups and shows the existence of three regions of distinct ...
Annick Panaye +2 more
openaire +1 more source
The steric effect of alkyl groups as characterized by the revised Taft E's parameter is analysed using an approach based on the DARC topological system and its PELCO correlation method. This approach involves an analysis of the systemativ variation of E's in a topological dequencing of alkyl groups and shows the existence of three regions of distinct ...
Annick Panaye +2 more
openaire +1 more source

