Results 231 to 240 of about 290,507 (301)

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

open access: yesAdvanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu   +7 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Selective CDK4/9 Inhibitors. [PDF]

open access: yesACS Med Chem Lett
Li S   +6 more
europepmc   +1 more source

Cyclometalated Ir(iii) complexes bridged by µ-OH and µ-3,5-bis(4-methoxyphenyl)-pyrazole ligands. [PDF]

open access: yesRSC Adv
Mausami   +8 more
europepmc   +1 more source

Steric effects in alkylpyrimidines

Recueil des Travaux Chimiques des Pays-Bas, 1978
AbstractTreatment of solutions of 4,6‐dimethylpyrimidine and 4,6‐di‐t‐butylpyrimidine in acid with aliphatic acids (RCO2H) in the presence of silver nitrate and ammonium peroxydisulfate gave the 2‐R‐4,6‐dimethyl‐ and 2‐R‐4,6‐di‐t‐butylpyrimidines (R = C2H5, i‐C3H7, t‐C4H9). Ths pKa values of these compounds were measured.
van der Plas, H.C., Koudijs, A.
openaire   +2 more sources

Steric effects-II

Tetrahedron, 1980
The steric effect of alkyl groups as characterized by the revised Taft E's parameter is analysed using an approach based on the DARC topological system and its PELCO correlation method. This approach involves an analysis of the systemativ variation of E's in a topological dequencing of alkyl groups and shows the existence of three regions of distinct ...
Annick Panaye   +2 more
openaire   +1 more source

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