Results 31 to 40 of about 146,285 (261)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Steric Effects of Alcohols on the [Mn4O4] Cubane-Type Structures
Crystals[M4O4] (M = 3d transition metal) represents an interesting class of compounds featuring cubane-type molecular structures, and particularly, [Mn4O4] cubanes or their derivatives attract much attention by virtue of their potential applications as single ...
Yan He, Zheng Zhou, Haixiang Han
doaj +1 more source
Al-Kitab Journal for Pure Sciences, 2023 Alkaline hydrolysis rates coefficients for the series of methyl 3-(7-substituted-1-naphthyl) propynoate was calculated in 70%v/v dimethylsulphoxide-water at various temperatures (25,30,40, and 50̊ C).
Khalaf D. F. Ghadir +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Late Transition Metal Olefin Polymerization Catalysts Derived from 8-Arylnaphthylamines
InorganicsLate transition metal catalysts represent a significant class of olefin polymerization catalysts that have played an essential role in advancing the polyolefin industry owing to their highly tunable ligands and low oxophilicity.
Zonglin Qiu +7 more
doaj +1 more source
Molecules, 2014 Intramolecular hydrogen bond (HB) formation was analyzed in the model compounds N-(2-benzoylphenyl)acetamide, N-(2-benzoylphenyl)oxalamate and N1,N2-bis(2-benzoylphenyl)oxalamide.
Carlos Z. Gómez-Castro +5 more
doaj +1 more source
Steric Effects Govern the Photoactivation of Phytochromes
ChemPhysChem, 2016 AbstractPhytochromes constitute a superfamily of photoreceptor proteins existing in two forms that absorb red (Pr) and far‐red (Pfr) light. Although it is well‐known that the conversion of Pr into Pfr (the biologically active form) is triggered by a Z→E photoisomerization of the linear tetrapyrrole chromophore, direct evidence is scarce as to why this ...
Olle Falklöf, Bo Durbeej
openaire +4 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Discover Chemistry1,2,3-Cyclohexatriene is highly reactive compound which is relatively underexplored compound, demonstrates significant potential for cycloaddition reactions.
Lalitha Ravichandran
doaj +1 more source
N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion
Frontiers in Cellular and Infection Microbiology, 2020 The Ebola Virus (EBOV) glycoprotein (GP) sterically shields cell-membrane ligands to immune receptors such as human leukocyte antigen class-1 (HLA-I) and MHC class I polypeptide-related sequence A (MICA), thus mediating immunity evasion. It was suggested
Muhammed Iraqi +12 more
doaj +1 more source