Results 101 to 110 of about 254,410 (141)

Inhibition of mtDNA-PRRs pathway-mediated sterile inflammation by astragalus polysaccharide protects against transport stress-induced cardiac injury in chicks. [PDF]

Poult Sci
Chen J, Xu WY, Gu Y, Tang YX, Xu XW, Li XN, Li JL.   +6 more
europepmc   +1 more source

Correction to: Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts. [PDF]

Circulation
europepmc   +1 more source

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. [PDF]

EMBO J
Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, La Manna F, Ciani Y, Vannuccini F, Mugoni V, Notarangelo M, Libergoli M, Broso F, Taulli R, Ala U, Savino A, Cortese M, Mirzaaghaei S, Poli V, Bonapace IM, Papotti MG, Molinaro L, Doglioni C, Caffo O, Anesi A, Nagler M, Bertalot G, Carbone FG, Barbareschi M, Basso U, Dassi E, Pizzato M, Romanel A, Demichelis F, Kruithof-de Julio M, Lunardi A.   +35 more
europepmc   +1 more source

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Biomaterials-Driven Sterile Inflammation

Tissue Engineering Part B: Reviews, 2022
Performance of the biomaterials used for regenerative medicine largely depends on biocompatibility; however, the biological mechanisms underlying biocompatibility of a biomaterial within the host system is poorly understood. In addition to the classical immune response against non-self-entities, the sterile inflammatory response could limit the ...
Henry, Chen, Devendra K, Agrawal, Finosh G, Thankam   +2 more
openaire   +2 more sources

Nucleic acid driven sterile inflammation

Clinical Immunology, 2013
The etiology of sterile inflammatory conditions is complex and affected by a variety of genetic, environmental and stochastic factors. But despite this overt complexity, progress has been made in elucidating mechanisms underlying disease pathogenesis. An intriguing new finding that has emerged over the past years was the realization that innate immune ...
Andrea, Ablasser, Carola, Hertrich, Ruth, Waßermann, Veit, Hornung   +3 more
openaire   +2 more sources

Sterile Inflammation in the Liver

Gastroenterology, 2012
Inflammation In the absence of pathogens occurs in all tissues in response to a wide range of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process in drug-induced liver injury, nonalcoholic steatohepatitis, and alcoholic steatohepatitis and is a major determinant of fibrosis and carcinogenesis.
Paul, Kubes, Wajahat Z, Mehal
openaire   +2 more sources

Molecular determinants of sterile inflammation

Current Opinion in Immunology, 2014
Necrotic cell death alerts the acquired immune system to activate naïve T cells even in the absence of non-self derived molecules (e.g. pathogens). In addition, sterile necrosis leads to innate immune-mediated acute inflammation. The dying cells still represent a threat to the body that should be eliminated by the host immune response.
Hajime, Kono, Akiko, Onda, Tamiko, Yanagida   +2 more
openaire   +2 more sources

CD137 reverse signaling in sterile inflammation: CD137L in sterile tissue inflammation

2012 7th International Forum on Strategic Technology (IFOST), 2012
CD137 (also called 4-1BB and TNFRSF9) has recently received attention as a therapeutic target for cancer and a variety of autoimmune and inflammatory diseases. Stimulating CD137 in vivo enhances CD8+ T cell-activity and results in strong immunosuppression in some contexts.
Byungsuk Kwon, Hong Rae Cho
openaire   +1 more source

ApoC3: an ‘alarmin’ triggering sterile inflammation

Nature Immunology, 2019
NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.
Tao Gong, Rongbin Zhou
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DAMPening sterile inflammation of the kidney

Kidney International, 2019
Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al.
Mirjam, Meissner, Susanne F, Viehmann, Christian, Kurts   +2 more
openaire   +2 more sources