Results 1 to 10 of about 49,115 (164)

AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke

Cell Reports, 2021
Summary: The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs.
Kaori Taniguchi, Hideaki Ando, Satoko Arai   +2 more
exaly   +3 more sources

DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma

Frontiers in Immunology
BackgroundDamage-associated molecular patterns (DAMPs) induced by immunogenic cell death (ICD) may be useful for the immunotherapy to patients undergoing pancreatic ductal adenocarcinoma (PDAC).
Qianxue Wu, Qian Xiao, Xin Tang
exaly   +3 more sources

DAMPs and radiation injury

Frontiers in Immunology
The heightened risk of ionizing radiation exposure, stemming from radiation accidents and potential acts of terrorism, has spurred growing interests in devising effective countermeasures against radiation injury.
Monowar Aziz, Max Brenner, Aziz Monowar   +2 more
exaly   +3 more sources

Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy [PDF]

BioImpacts, 2023
Introduction: Silibinin is a natural flavonoid compound known to induce apoptosis in cancer cells. Despite silibinin's safety and efficacy as an anticancer drug, its effects on inducing immunogenic cell death (ICD) are largely unknown.
Sevda Jafari, Saba Heydarian, Raymond Lai, Elnaz Mehdizadeh Aghdam, Ommoleila Molavi   +4 more
doaj   +1 more source

Pseudospectra of the Damped Wave Equation with Unbounded Damping [PDF]

SIAM Journal on Mathematical Analysis, 2020
We analyze pseudospectra of the generator of the damped wave equation with unbounded damping. We show that the resolvent norm diverges as $\Re z \to - \infty$. The highly non-normal character of the operator is a robust effect preserved even when a strong potential is added.
Ahmet Arifoski, Petr Siegl
openaire   +5 more sources

Can High Mobility Group Box 1 Protein Predict Ongoing Subclinical Inflammation in Patients With Familial Mediterranean Fever?

Journal of Behçet Uz Children's Hospital, 2023
Objective: Familial Mediterranean fever (FMF) is an autoinflammatory disease that commonly presents with fever, peritonitis, and pleuritis. Recent studies have reported ongoing inflammation in the attack-free period of patients with FMF.
Betül Öztürk, Esra Baskın, Kaan Gülleroğlu, Begüm Avcı, Nilüfer Bayraktar, Feride İffet Şahin   +5 more
doaj   +1 more source

DAMP-mediated inflammation and regulated cell death in immunoinflammatory rheumatic diseases

Медицинская иммунология, 2023
The state of autoreactivity of innate immunity dominates in the pathogenesis of immunoinflammatory rheumatic diseases,  inducing non-infectious “sterile” inflammation.
M. Z. Saidov
doaj   +1 more source

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’ [PDF]

Ageing Research Reviews, 2015
Ageing is a complex and multifactorial process characterized by the accumulation of many forms of damage at the molecular, cellular, and tissue level with advancing age. Ageing increases the risk of the onset of chronic inflammation-associated diseases such as cancer, diabetes, stroke, and neurodegenerative disease.
Jin, Huang, Yangchun, Xie, Xiaofang, Sun, Herbert J, Zeh, Rui, Kang, Michael T, Lotze, Daolin, Tang   +6 more
openaire   +2 more sources

Using PAMPs and DAMPs as adjuvants in cancer vaccines

Human Vaccines & Immunotherapeutics, 2021
Immunotherapy for cancer has attracted considerable attention. As one of the immunotherapeutics, tumor vaccines exert great potential for cancer immunotherapy.
Huanyou Sun, Wenwen Hu, Yinan Yan, Zichun Zhang, Yuxin Chen, Xuefan Yao, Ling Teng, Xinyuan Wang, Dafei Chai, Junnian Zheng, Gang Wang   +10 more
doaj   +1 more source

Immunogenic Cell Death-Relevant Damage-Associated Molecular Patterns and Sensing Receptors in Triple-Negative Breast Cancer Molecular Subtypes and Implications for Immunotherapy

Frontiers in Oncology, 2022
ObjectivesTriple-negative breast cancer (TNBC) is defined as a highly aggressive type of breast cancer which lacks specific biomarkers and drug targets.
Ming Xu, Ming Xu, Jin-hua Lu, Ya-zhen Zhong, Jing Jiang, Yue-zhong Shen, Jing-yang Su, Sheng-you Lin   +7 more
doaj   +1 more source